ArticleBiophysical journal1989
Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor).
Article in Biophysical journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 120 citations in OpenAlex.
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- Cellular basis of learning and memory in the carotid body.Frontiers in synaptic neuroscience · 2022Review
- Transcriptome sequencing of olfactory-related genes in olfactory transduction of large yellow croaker (PeerJ · 2019Article
- Distinct temporal filters in mitral cells and external tufted cells of the olfactory bulb.The Journal of physiology · 2017Article
- The long tale of the calcium activated ClChannels (Austin, Tex.) · 2017Review
- Spontaneously active NaV1.5 sodium channels may underlie odor sensitivity.Journal of neurophysiology · 2016Article
- Properties of an optogenetic model for olfactory stimulation.The Journal of physiology · 2016Article
- Circuit formation and function in the olfactory bulb of mice with reduced spontaneous afferent activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons.Journal of neurophysiology · 2014Article
- From molecule to mind: an integrative perspective on odor intensity.Trends in neurosciences · 2014Review
- The ISI distribution of the stochastic Hodgkin-Huxley neuron.Frontiers in computational neuroscience · 2014Article
- Common dynamical features of sensory adaptation in photoreceptors and olfactory sensory neurons.Scientific reports · 2013Article
- Properties of subependymal cerebrospinal fluid contacting neurones in the dorsal vagal complex of the mouse brainstem.The Journal of physiology · 2012Article
- Measuring the firing rate of high-resistance neurons with cell-attached recording.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Persistent membranous cross correlations due to the multiplicity of gates in ion channels.Journal of computational neuroscience · 2011Article
- Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons.Molecular pain · 2011Article
- Signaling by olfactory receptor neurons near threshold.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Gap junctions in olfactory neurons modulate olfactory sensitivity.BMC neuroscience · 2010Article
- Detailed numerical investigation of the dissipative stochastic mechanics based neuron model.Journal of computational neuroscience · 2008Article
- Stochastic differential equation model for cerebellar granule cell excitability.PLoS computational biology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rat olfactory receptor neurons were enzymatically dissociated and studied with the cell-attached configuration of the patch-clamp technique. Biphasic current waveforms induced across the membrane patch by intracellular action potentials were observed in approximately 5% of cells studied. In one cell in particular, current injected by the opening of a single channel initiated an action potential in the remainder of the cell each time the channel opened. A conventional type of electrical model of the cell and patch allowed the accurate modeling of cell excitability. The same model was used to explain the shape of the action potential current waveforms induced across the patch. The analysis indicated that the whole cell resistance (Ro) was approximately 40 G omega and the membrane capacitance (Co) was close to the standard value of 1 microF.cm-2. In addition, the threshold potential change necessary to initiate an action potential (Vth) was approximately 13 mV and a minimum current injection of 1 pA was required to depolarize the cell to spike threshold. When the smaller size of mammalian receptors are taken into account, membrane electrical properties were found to be consistent with those of salamander cells investigated by others using whole-cell recording. The analysis also revealed possible errors in the determination of single-channel conductances and reversal potentials by cell-attached recording from small cells.
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