ArticleInsect biochemistry and molecular biology2014
Molecular biology of insect sodium channels and pyrethroid resistance.
Article in Insect biochemistry and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 219 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
219 citing papers in PubMed, 1 synthesis or guideline pooled it, 538 citations in OpenAlex.
- Knockdown resistance (kdr) and organochlorine insecticide resistance in malaria vectors: a systematic review.Malaria journal · 2025Pooled it
- Mutations M918T, M918L, and L1014F impair pyrethroid binding and alter gating of the Megalurothrips usitatus sodium channel.Pest management science · 2026Article
- High Pyrethroid Resistance inInsects · 2026Article
- Article
- Changes in Alternative Splicing are Associated with Insecticide Response and Resistance.Genome biology and evolution · 2026Article
- Genotypic detection of synthetic pyrethroid and organophosphate resistance-associated mutations in Rhipicephalus (Boophilus) microplus infesting ruminants across three agro-ecological zones in Pakistan.Experimental & applied acarology · 2026Article
- Insecticide susceptibility and knockdown resistance (Kdr) mutations (F1534C and V1016I) in Aedes aegypti populations from Dar es Salaam, Tanzania.Parasites & vectors · 2026Article
- Insecticide Resistance Dynamics and Gene Screening inInsects · 2026Article
- Article
- A genome sequence and efficient CRISPR/Cas9 gene editing tools for the solanaceous specialist pest Tetranychus evansi.Insect biochemistry and molecular biology · 2026Article
- Synthetic pyrethroid resistance in Haematobia irritans subsp. exigua (Diptera: Muscidae): knockdown-recovery observed, a new putative resistance-linked mutation detected, and a complete voltage-gated sodium channel gene transcript sequenced.Journal of economic entomology · 2026Article
- Callosal glia, GABAergic interneurons, and apoptotic profiles in the brains of cypermethrin-exposed male and female rats.BMC research notes · 2026Article
- Assessing phototaxis behavior in non-resistant and insecticide-resistant populations of Hyalella azteca.Ecotoxicology (London, England) · 2026Article
- Widespread pyrethroid resistance in Varroa destructor in Türkiye: a molecular warning.Experimental & applied acarology · 2026Article
- Genomic Signatures of Microgeographic Adaptation in Anopheles coluzzii Across Urban, Rural, and Forested Environments in Gabon.Molecular ecology · 2026Article
- Presence of localized elevated metabolic enzymes and kdr mutations in the voltage-gated sodium channel gene indicate early evidence of resistance of Phlebotomus argentipes to alpha-cypermethrin in Bihar, India.Parasites & vectors · 2026Article
- The diversity of insecticide target site mutations in Apis mellifera.BMC genomics · 2026Article
- Structural insights into insect-selective sodium channel toxins drive AI-enhanced biopesticide design.Nature communications · 2026Article
- Whole-Genome Resequencing of the VGSC Reveals the Evolutionary Mechanism of Pesticide Resistance inInternational journal of molecular sciences · 2026Article
- F1534SFrontiers in cellular and infection microbiology · 2026Article
159 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Voltage-gated sodium channels are essential for the initiation and propagation of the action potential in neurons and other excitable cells. Because of their critical roles in electrical signaling, sodium channels are targets of a variety of naturally occurring and synthetic neurotoxins, including several classes of insecticides. This review is intended to provide an update on the molecular biology of insect sodium channels and the molecular mechanism of pyrethroid resistance. Although mammalian and insect sodium channels share fundamental topological and functional properties, most insect species carry only one sodium channel gene, compared to multiple sodium channel genes found in each mammalian species. Recent studies showed that two posttranscriptional mechanisms, alternative splicing and RNA editing, are involved in generating functional diversity of sodium channels in insects. More than 50 sodium channel mutations have been identified to be responsible for or associated with knockdown resistance (kdr) to pyrethroids in various arthropod pests and disease vectors. Elucidation of molecular mechanism of kdr led to the identification of dual receptor sites of pyrethroids on insect sodium channels. Many of the kdr mutations appear to be located within or close to the two receptor sites. The accumulating knowledge of insect sodium channels and their interactions with insecticides provides a foundation for understanding the neurophysiology of sodium channels in vivo and the development of new and safer insecticides for effective control of arthropod pests and human disease vectors.
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Registered trials
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