ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2014
Performance of creatinine-based GFR estimating equations in solid-organ transplant recipients.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 123 citations in OpenAlex.
- Multicenter Study to Transplant Hepatitis C-Infected Kidneys (MYTHIC): An Open-Label Study of Combined Glecaprevir and Pibrentasvir to Treat Recipients of Transplanted Kidneys from Deceased Donors with Hepatitis C Virus Infection.Journal of the American Society of Nephrology : JASN · 2020Trial
- Albuminuria and Allograft Failure, Cardiovascular Disease Events, and All-Cause Death in Stable Kidney Transplant Recipients: A Cohort Analysis of the FAVORIT Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Trial
- Serum Phosphorus and Risk of Cardiovascular Disease, All-Cause Mortality, or Graft Failure in Kidney Transplant Recipients: An Ancillary Study of the FAVORIT Trial Cohort.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Trial
- Reply: Chronic kidney disease after liver transplantation: Accurate measurement, early acute kidney injury, and renal-protective strategies.World journal of transplantation · 2026Article
- Chronic kidney disease at one year after liver transplantation: Role of changes in immunosuppression over three decades.World journal of transplantation · 2025Article
- Prediction of Kidney Function Improvement After Heart Transplantation.Biomedicines · 2025Article
- Mortality and Graft Failure With Medical Management Alone Versus Revascularization After Coronary Angiography Among Kidney Transplant Recipients: A Population-Based Study.Canadian journal of kidney health and disease · 2025Article
- Long non-coding RNA MGAT3 in kidney transplant recipients with immunoglobulin A nephropathy.Journal of nephrology · 2024Article
- Do We Need a New Creatinine-Based Estimated GFR Equation for Kidney Transplant Recipients?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- GFR estimated with creatinine rather than cystatin C is more reflective of the true risk of adverse outcomes with low GFR in kidney transplant recipients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array.Scientific reports · 2023Article
- Time to Rethink the Current Paradigm for Assessing Kidney Function in Drug Development and Beyond.Clinical pharmacology and therapeutics · 2022Review
- Kidney disease in non-kidney solid organ transplantation.World journal of transplantation · 2022Review
- Association of donor hepatitis C virus infection status and risk of BK polyomavirus viremia after kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Remnant cholesterol is prospectively associated with cardiovascular disease events and all-cause mortality in kidney transplant recipients: the FAVORIT study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Performance and Determinants of Serum Creatinine and Cystatin C-Based GFR Estimating Equations in South Asians.Kidney international reports · 2021Article
- Graft Function, Albuminuria, and the Risk of Hemorrhage and Thrombosis After Kidney Transplantation.Canadian journal of kidney health and disease · 2020Article
- Incidence, Risk Factors, and Outcomes of Kidney Transplant Recipients Treated With Both Basiliximab and Antithymocyte Globulin.Canadian journal of kidney health and disease · 2020Article
- Comparison of creatinine-based equations for estimating glomerular filtration rate in deceased donor renal transplant recipients.PloS one · 2020Article
- Mortality and Morbidity in Kidney Transplant Recipients With a Failing Graft: A Matched Cohort Study.Canadian journal of kidney health and disease · 2020Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundAccurate assessment of kidney function is important for the management of solid-organ transplant recipients. In other clinical populations, glomerular filtration rate (GFR) most commonly is estimated using the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) creatinine or the 4-variable MDRD (Modification of Diet in Renal Disease) Study equation. The accuracy of these equations compared with other GFR estimating equations in transplant recipients has not been carefully studied. STUDY
designDiagnostic test study. SETTING &
participantsSolid-organ transplant recipients longer than 6 months posttransplantation from 5 clinical populations (N=3,622, including recipients of kidney [53%], liver [35%], and other or multiple organs [12%]). INDEX TEST: Estimated GFR (eGFR) using creatinine-based GFR estimating equations identified from a systematic review of the literature. Performance of the CKD-EPI creatinine and the MDRD Study equations was compared with alternative equations. REFERENCE TEST: Measured GFR (mGFR) from urinary clearance of iothalamate or plasma clearance of iohexol. MEASUREMENTS: Error (difference between mGFR and eGFR) expressed as P30 (proportion of absolute percent error <30%) and mean absolute error.
resultsWe identified 26 GFR estimating equations. Mean mGFR was 55.1±22.7 (SD) mL/min/1.73 m(2). P30 and mean absolute error for the CKD-EPI and the MDRD Study equations were 78.9% (99.6% CI, 76.9%-80.8%) for both and 10.6 (99.6% CI, 10.1-11.1) versus 11.0 (99.6% CI, 10.5-11.5) mL/min/1.73 m(2), respectively; these equations were more accurate than any of the alternative equations (P <0.001 for all pairwise comparisons for both measures). They performed better than or as well as the alternative equations in most subgroups defined by demographic and clinical characteristics, including type of transplanted organ. LIMITATIONS: Study population included few nonwhites and people with solid-organ transplants other than liver and kidneys.
conclusionsThe CKD-EPI creatinine and the MDRD Study equations perform better than the alternative creatinine-based estimating equations in solid-organ transplant recipients. They can be used for clinical management.
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