Evidence map›Paper›PMID 24703688›Full record

ArticleCell metabolism2014

Metabolism goes viral.

Shigeki J Miyake-Stoner, Clodagh C O'Shea

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Metabolome-Driven Regulation of Adenovirus-Induced Cell Death.International journal of molecular sciences · 2021
    Review
  5. Protein-protein interactions of human viruses.Seminars in cell & developmental biology · 2020
    Review
  6. Review
  7. Viral Infections and Obesity.Current obesity reports · 2017
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Shigeki J Miyake-StonerMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA.
Clodagh C O'SheaMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA. Electronic address: oshea@salk.edu.

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8M
GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
Defining Critical p53 Therapeutic Targets and MechanismsR01CA137094 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI O'SHEA, CLODAGH · 2009 to 2019
$4.1M
NCI NIH HHS P30 CA014195NCI NIH HHS P30CA014195NCI NIH HHS R01 CA137094NCI NIH HHS R01CA137094NIGMS NIH HHS T32 GM007240NIGMS NIH HHS T32 GM007240-35
6 · The paper itself

Abstract

Viral and cellular oncogenes converge in targeting critical protein interaction networks to reprogram the cellular DNA and protein replication machinery for pathological replication. In this issue, Thai et al. (2014) show that adenovirus E4ORF1 activates MYC glycolytic targets to induce a Warburg-like effect that converts glucose into nucleotides for viral replication.

Indexed as

Models, BiologicalAdenovirus E4 ProteinsEpithelial CellsGlucoseHumansMetabolic Networks and PathwaysProto-Oncogene Proteins c-mycVirus ReplicationAdenovirus E4 ProteinsGlucoseMYC protein, humanProto-Oncogene Proteins c-myc

Identifiers

PMID24703688
PMCPMC4097405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.