Evidence map›Paper›PMID 24703682›Full record

ArticleAnnals of epidemiology2014

Exploring the association between melanoma and glioma risks.

Peter M Scarbrough, Igor Akushevich, Margaret Wrensch, Dora Il'yasova

Open access · greenAbstract read
In one paragraph

Article in Annals of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Molecular principles underlying aggressive cancers.Signal transduction and targeted therapy · 2025
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  9. American journal of cancer research · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Learning a Latent Space of Highly Multidimensional Cancer Data.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. MiR-21: an environmental driver of malignant melanoma?Journal of translational medicine · 2015
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Peter M ScarbroughDuke Cancer Institute, Duke University Medical Center, Durham, NC.
Igor AkushevichDuke Cancer Institute, Duke University Medical Center, Durham, NC.
Margaret WrenschDepartment of Neurological Surgery, University of California, San Francisco, San Francisco.
Dora Il'yasovaDuke Cancer Institute, Duke University Medical Center, Durham, NC; Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta. Electronic address: dilyasova@gsu.edu.
Duke Medical Center · USUniversity of California, San Francisco · US

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5M
International Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0M
TRAINING PROGRAM IN FREE RADICAL AND RADIATION BIOLOGYT32CA078586 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 1999 to 2024
$5.7M
Integrating Population and Basic Science in Cancer ResearchR25CA126938 · NCI · DUKE UNIVERSITY · PI SCHILDKRAUT, JOELLEN M. · 2009 to 2013
$1.7M
NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA139020NCI NIH HHS R01CA139020NCI NIH HHS R25 CA126938NCI NIH HHS R25CA12693804NCI NIH HHS T32 CA078586
6 · The paper itself

Abstract

purposeGliomas are one of the most fatal malignancies, with largely unknown etiology. This study examines a possible connection between glioma and melanoma, which might provide insight into gliomas' etiology.

methodsUsing data provided by the Surveillance, Epidemiology, and End Results program from 1992 to 2009, a cohort was constructed to determine the incidence rates of glioma among those who had a prior diagnosis of invasive melanoma. Glioma rates in those with prior melanoma were compared with those in the general population.

resultsThe incidence rate of all gliomas was greater among melanoma cases than in the general population: 10.46 versus 6.13 cases per 100,000 person-years, standardized incidence ratios = 1.42 (1.22-1.62). The female excess rate was slightly greater (42%) than that among males (29%). Sensitivity analyses did not reveal evidence that radiation treatment of melanoma is responsible for the detected gap in the rates of gliomas.

conclusionsOur analysis documented increased risk of glioma among melanoma patients. Because no common environmental risk factors are identified for glioma and melanoma, it is hypothesized that a common genetic predisposition may be responsible for the detected association.

Indexed as

AdultAgedCohort StudiesFemaleGliomaHumansIncidenceMaleMelanomaMiddle AgedRisk FactorsSEER ProgramSex DistributionSkin NeoplasmsUnited StatesEpidemiologyGlioblastomaGliomaMelanomaSEER

Identifiers

PMID24703682
PMCPMC4111084
OpenAlexW2137017044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.