ArticleActa physiologica (Oxford, England)2015
Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance.
Article in Acta physiologica (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The Impact of the Metabolic Syndrome Severity on the Appearance of Primary and Permanent DNA Damage.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Towards a validation of the standard and enzyme-linked comet assay: a retrospective variability analysis.Archives of toxicology · 2026Review
- The effects of exercise on epigenetic modifications: focus on DNA methylation, histone modifications and non-coding RNAs.Human cell · 2024Review
- ROS production by mitochondria: function or dysfunction?Oncogene · 2024Review
- Do Active Commuters Feel More Competent and Vital? A Self-Organizing Maps Analysis in University Students.International journal of environmental research and public health · 2022Article
- Regular, Intense Exercise Training as a Healthy Aging Lifestyle Strategy: Preventing DNA Damage, Telomere Shortening and Adverse DNA Methylation Changes Over a Lifetime.Frontiers in genetics · 2021Review
- The Radioprotective Effect of Procaine and Procaine-Derived Product Gerovital H3 in Lymphocytes from Young and Aged Individuals.Oxidative medicine and cellular longevity · 2020Article
- Influence of Acute Exercise on DNA Repair and PARP Activity before and after Irradiation in Lymphocytes from Trained and Untrained Individuals.International journal of molecular sciences · 2019Article
- The association between life satisfaction, vitality, self-rated health, and risk of cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Factor structure and measurement invariance of the Subjective Vitality Scale: evidence from Chinese adolescents in Hong Kong.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Prospective Associations of the Short Form Health Survey Vitality Scale and Changes in Body Mass Index and Obesity Status.Journal of obesity · 2018Article
- Associations of Leukocyte Telomere Length With Aerobic and Muscular Fitness in Young Adults.American journal of epidemiology · 2017Article
- Emerging metrology for high-throughput nanomaterial genotoxicology.Mutagenesis · 2017Review
- Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training.Sports medicine (Auckland, N.Z.) · 2016Review
- Article
- DNA Damage, DNA Repair, Aging, and Neurodegeneration.Cold Spring Harbor perspectives in medicine · 2015Review
- Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells.Oncotarget · 2015Article
- The role of RecQ helicases in non-homologous end-joining.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 3 countries.
Funding
Abstract
aimTo examine associations of DNA damage, cardiovascular risk factors and physical performance with vitality, in middle-aged men. We also sought to elucidate underlying factors of physical performance by comparing physical performance parameters to DNA damage parameters and cardiovascular risk factors.
methodsWe studied 2487 participants from the Metropolit cohort of 11 532 men born in 1953 in the Copenhagen Metropolitan area. The vitality level was estimated using the SF-36 vitality scale. Cardiovascular risk factors were determined by body mass index (BMI), and haematological biochemistry tests obtained from non-fasting participants. DNA damage parameters were measured in peripheral blood mononuclear cells (PBMCs) from as many participants as possible from a representative subset of 207 participants.
resultsVitality was inversely associated with spontaneous DNA breaks (measured by comet assay) (P = 0.046) and BMI (P = 0.002), and positively associated with all of the physical performance parameters (all P < 0.001). Also, we found several associations between physical performance parameters and cardiovascular risk factors. In addition, the load of short telomeres was inversely associated with maximum jump force (P = 0.018), with lowered significance after exclusion of either arthritis sufferers (P = 0.035) or smokers (P = 0.031).
conclusionHere, we show that self-reported vitality is associated with DNA breaks, BMI and objective (measured) physical performance in a cohort of middle-aged men. Several other associations in this study verify clinical observations in medical practice. In addition, the load of short telomeres may be linked to peak performance in certain musculoskeletal activities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.