Evidence map›Paper›PMID 24703167›Full record

Trial reportPsychoneuroendocrinology2014

Yoga reduces inflammatory signaling in fatigued breast cancer survivors: a randomized controlled trial.

Julienne E Bower, Gail Greendale, Alexandra D Crosswell, Deborah Garet, Beth Sternlieb, Patricia A Ganz, Michael R Irwin, Richard Olmstead, Jesusa Arevalo, Steve W Cole

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychoneuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 161 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 20 pooled it
7.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04457895 narecruitingnot on this mapstarted 2021, after this paper: background citation

A Randomized, Open-labelled, Controlled Trial Evaluating the Efficacy of a Physical Therapy-yoga-patient Educational Program for Breast Cancer Patients With Pain Due to Hormonal Therapy Treatment.

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2021 to 2028Enrolled108ConditionsBreast CancerArmseducational yoga program, no intervention
NCT06540612 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Aerobic Exercise on Cancer-Related Biomarkers, Functional Capacity, Cognitive Status and Quality of Life in Women With Breast Cancer

TypeinterventionalSponsorHasan Kalyoncu UniversityRan2024 to 2026Enrolled69ConditionsBreast Cancer Female, Quality of Life, SurvivorshipArmsAerobic exercise, Physical activity counseling
3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 20 syntheses or guidelines pooled it, 270 citations in OpenAlex.

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  9. Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
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  11. Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
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  16. Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018
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  17. Yoga for stroke rehabilitation.The Cochrane database of systematic reviews · 2017
    Pooled it
  18. A systematic review of yoga interventions as integrative treatment in breast cancer.Journal of cancer research and clinical oncology · 2016
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  20. Use of Salivary Diurnal Cortisol as an Outcome Measure in Randomised Controlled Trials: a Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016
    Pooled it

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Julienne E BowerUCLA Department of Psychology, Los Angeles, CA, United States; UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, United States; Cousins Center for Psychoneuroimmunology, Semel Institute at UCLA, Los Angeles, CA, United States; Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA, United States. Electronic address: jbower@ucla.edu.
Gail GreendaleUCLA Department of Geriatrics, Los Angeles, CA, United States.
Alexandra D CrosswellUCLA Department of Psychology, Los Angeles, CA, United States.
Deborah GaretCousins Center for Psychoneuroimmunology, Semel Institute at UCLA, Los Angeles, CA, United States.
Beth SternliebPediatric Pain Program, Mattel Children's Hospital at UCLA, Los Angeles, CA, United States.
Patricia A GanzJonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA, United States; UCLA Schools of Medicine and Public Health, Los Angeles, CA, United States.
Michael R IrwinUCLA Department of Psychology, Los Angeles, CA, United States; UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, United States; Cousins Center for Psychoneuroimmunology, Semel Institute at UCLA, Los Angeles, CA, United States; Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA, United States.
Richard OlmsteadUCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, United States; Cousins Center for Psychoneuroimmunology, Semel Institute at UCLA, Los Angeles, CA, United States.
Jesusa ArevaloUCLA Department of Medicine, Los Angeles, CA, United States.
Steve W ColeCousins Center for Psychoneuroimmunology, Semel Institute at UCLA, Los Angeles, CA, United States; UCLA Department of Medicine, Los Angeles, CA, United States.
University of California, Los Angeles · USBoston Children's Hospital · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Melissa Fitzmaurice Neligan · 1985 to 2026
$134.5M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2017
$9.8M
Integrated Training in the Population, Behavioral, and Biomedical SciencesT32GM084903 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E · 2009 to 2013
$788k
Iyengar Yoga for Breast Cancer Survivors with Persistent FatigueU01AT003682 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E · 2006 to 2008
$604k
NCCIH NIH HHS U01 AT003682NCI NIH HHS P30 CA016042NIA NIH HHS P30 AG028748NIGMS NIH HHS T32 GM084903
6 · The paper itself

Abstract

backgroundYoga is a popular mind-body therapy that has demonstrated beneficial effects on psychological, behavioral, and functional outcomes. However, few studies have investigated effects on inflammatory processes. This study tested the hypothesis that an Iyengar yoga intervention specifically designed for fatigued breast cancer survivors would lead to decreases in inflammation-related gene expression and circulating markers of proinflammatory cytokine activity.

methodsBreast cancer survivors with persistent cancer-related fatigue were randomized to a 12-week Iyengar yoga intervention (n=16) or a 12-week health education control condition (n=15). Blood samples were collected at baseline, post-intervention, and at a 3-month follow-up for genome-wide transcriptional profiling and bioinformatic analyses. Plasma inflammatory markers and salivary cortisol were also assessed.

resultsIn promoter-based bioinformatics analyses, the yoga group showed reduced activity of the pro-inflammatory transcription factor nuclear factor kappa B (NF-κB), increased activity of the anti-inflammatory glucocorticoid receptor, and reduced activity of cAMP response element-binding protein (CREB) family transcription factors relative to controls (all ps<.05). There was also a significant intervention effect on the soluble tumor necrosis factor receptor type II (sTNF-RII), a marker of TNF activity; plasma levels of sTNF-RII remained stable in the yoga group, whereas levels of this marker increased in the health education group (p=.028). A similar, non-significant trend was observed for the interleukin 1 receptor antagonist (p=.16). No significant changes in C reactive protein (CRP), interleukin 6 (IL-6), or diurnal cortisol measures were observed.

conclusionsA 12-week restorative Iyengar yoga intervention reduced inflammation-related gene expression in breast cancer survivors with persistent fatigue. These findings suggest that a targeted yoga program may have beneficial effects on inflammatory activity in this patient population, with potential relevance for behavioral and physical health.

Indexed as

Signal TransductionYogaBreast NeoplasmsComputational BiologyCytokinesFatigueFemaleGene Expression ProfilingHumansHydrocortisoneInflammationMiddle AgedSurvivorsCytokinesHydrocortisoneCancerCortisolFatigueGene expressionInflammationYoga

Identifiers

PMID24703167
PMCPMC4060606
OpenAlexW2133441071

What OpenQuestion holds

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LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.