ArticlePsychoneuroendocrinology2014
Oxytocin receptor gene polymorphism (rs53576) moderates the intergenerational transmission of depression.
Article in Psychoneuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 76 citations in OpenAlex.
- Effects of Intranasal Oxytocin Across Various Depressive Disorders.Psychiatry investigation · 2025Article
- Salivary oxytocin and amygdalar alterations in functional neurological disorders.Brain communications · 2025Article
- The Mood, Mother and Child Study: Protocol for a Prospective Longitudinal Study and Randomized Controlled Trial.JMIR research protocols · 2023Article
- Intertwined associations between oxytocin, immune system and major depressive disorder.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Review
- Resilience by design: How nature, nurture, environment, and microbiome mitigate stress and allostatic load.World journal of psychiatry · 2023Review
- Roles of the Oxytocin Receptor (OXTR) in Human Diseases.International journal of molecular sciences · 2023Review
- Hunting for Genes Underlying Emotionality in the Laboratory Rat: Maps, Tools and Traps.Current neuropharmacology · 2023Review
- The interaction of the oxytocin receptor gene and child abuse subtypes on social cognition in euthymic patients with bipolar disorder type I.Frontiers in psychiatry · 2023Article
- Oxytocin receptor single nucleotide polymorphism predicts atony-related postpartum hemorrhage.BMC pregnancy and childbirth · 2022Article
- Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting.Brain and behavior · 2021Article
- An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social-emotional mediators.Development and psychopathology · 2021Article
- Intergenerational Transmission of Cortical Sulcal Patterns from Mothers to their Children.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Intergenerational transmission: Theoretical and methodological issues and an introduction to four Dutch cohorts.Developmental cognitive neuroscience · 2020Review
- Genetic risk-factors for anxiety in healthy individuals: polymorphisms in genes important for the HPA axis.BMC medical genetics · 2020Article
- Oxytocin receptor gene, childhood maltreatment and borderline personality disorder features among male inmates in China.BMC psychiatry · 2020Article
- Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems.Scientific reports · 2019Article
- Oxytocin receptor gene variants are associated with emotion recognition and resilience, but not with false-belief reasoning performance in healthy young Korean volunteers.CNS neuroscience & therapeutics · 2019Article
- TheDiabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Increased aggression and lack of maternal behavior in Dio3-deficient mice are associated with abnormalities in oxytocin and vasopressin systems.Genes, brain, and behavior · 2018Article
- The association of childhood maltreatment with depression and anxiety is not moderated by the oxytocin receptor gene.European archives of psychiatry and clinical neuroscience · 2017Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
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Abstract
Maternal depression serves as a potent source of stress among offspring, greatly enhancing the risk of numerous adverse outcomes including youth depression. Several factors moderate the transmission of depression from mothers to offspring. However, the role of genetic characteristics in this process merits further exploration. Consistent with an interpersonal perspective on depression, the present study focused on a genetic polymorphism that has been shown to be relevant to social functioning, the rs53576 polymorphism of the oxytocin receptor gene (OXTR). In a community sample of 441 youth, OXTR genotype moderated the association between maternal depression in early childhood and youth depressive symptoms in adolescence, such that youth possessing at least one A allele of OXTR who also had a history of maternal depression exhibited the highest levels of depressive symptoms at age 15. In order to explore possible interpersonal mediators of this effect, conditional process analyses examined the role of youth social functioning in adolescence. Results suggest that OXTR genotype may partially account for the transmission of maternal depression to youth and support the role of dysfunctional social processes as a mechanism through which OXTR influences the development of depressive symptoms.
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