Evidence map›Paper›PMID 24703100›Full record

ArticleHuman pathology2014

Clear cell papillary renal cell carcinoma: micro-RNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma.

Enrico Munari, Luigi Marchionni, Apurva Chitre, Masamichi Hayashi, Guido Martignoni, Matteo Brunelli, Stefano Gobbo, Pedram Argani, Mohamad Allaf, Mohammad O Hoque and 1 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Human pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  11. Review
  12. Characteristics of Clear Cell Papillary Renal Cell Carcinoma (ccpRCC).International journal of molecular sciences · 2021
    Review
  13. Article
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  17. LncRNA SNHG5 regulates SOX4 expression through competitive binding to miR-489-3p in acute myeloid leukemia.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Enrico MunariDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA.
Luigi MarchionniDepartment of Oncology, Johns Hopkins University, Baltimore, MD 21287, USA.
Apurva ChitreDepartment of Oncology, Johns Hopkins University, Baltimore, MD 21287, USA.
Masamichi HayashiDepartment of Otolaryngology, Johns Hopkins University, Baltimore, MD 21287, USA.
Guido MartignoniDepartment of Pathology and Diagnostics, University of Verona, Verona 37134, Italy; Anatomic Pathology, Pederzoli Hospital, Peschiera d/G, Verona 37019, Italy.
Matteo BrunelliDepartment of Pathology and Diagnostics, University of Verona, Verona 37134, Italy.
Stefano GobboDepartment of Pathology and Diagnostics, University of Verona, Verona 37134, Italy; Anatomic Pathology, Pederzoli Hospital, Peschiera d/G, Verona 37019, Italy.
Pedram ArganiDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA.
Mohamad AllafDepartment of Urology, Johns Hopkins University, Baltimore, MD 21287, USA.
Mohammad O HoqueDepartment of Otolaryngology, Johns Hopkins University, Baltimore, MD 21287, USA. Electronic address: mhoque1@jhmi.edu.
George J NettoDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA; Department of Oncology, Johns Hopkins University, Baltimore, MD 21287, USA; Department of Urology, Johns Hopkins University, Baltimore, MD 21287, USA. Electronic address: gnetto1@jhmi.edu.
Johns Hopkins University · USUniversity of Verona · IT

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade renal neoplasm with morphological characteristics mimicking both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC). However, despite some overlapping features, their morphological, immunohistochemical, and molecular profiles are distinct. Micro-RNAs (miRNAs) are small noncoding RNAs that play a crucial role in regulating gene expression and are involved in various biological processes, including cancer development. To better understand the biology of this tumor, we aimed to analyze the miRNA expression profile of a set of CCPRCC using microarray and quantitative reverse transcription-polymerase chain reaction. A total of 15 cases diagnosed as CCPRCC were used in this study. Among the most differentially expressed miRNA in CCPRCC, we found miR-210, miR-122, miR-34a, miR-21, miR-34b*, and miR-489 to be up-regulated, whereas miR-4284, miR-1202, miR-135a, miR-1973, and miR-204 were down-regulated compared with normal renal parenchyma. To identify consensus of differentially regulated miRNA between CCPRCC, CCRCC, and PRCC, we additionally determined differential miRNA expression using 2 publically available microarray data sets from the NCBI Gene Expression Omnibus database (GSE41282 and GSE3798). This comparison revealed that the miRNA expression profile of CCPRCC shows some overlapping characteristics between CCRCC and PRCC. Moreover, CCPRCC lacks dysregulation of important miRNAs typically associated with aggressive behavior. In summary, we describe the miRNA expression profile of a relatively infrequent type of renal cancer. Our results may help in understanding the molecular underpinning of this newly recognized entity.

Indexed as

TranscriptomeAdultAgedCarcinoma, PapillaryCarcinoma, Renal CellFemaleGene Expression ProfilingHumansKidney NeoplasmsMaleMicroRNAsMiddle AgedOligonucleotide Array Sequence AnalysisReverse Transcriptase Polymerase Chain ReactionMicroRNAsClear cell papillary renal cell carcinomaMicro-RNAProfilingRenal cancer

Identifiers

PMID24703100
PMCPMC4332813
OpenAlexW2027974886

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.