Evidence map›Paper›PMID 24703006›Full record

ArticleMicrocirculation (New York, N.Y. : 1994)2014

Non-Newtonian flow of blood in arterioles: consequences for wall shear stress measurements.

Krishna Sriram, Marcos Intaglietta, Daniel M Tartakovsky

Open access · greenAbstract readComparative StudyValidation Study
In one paragraph

Article in Microcirculation (New York, N.Y. : 1994), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 88 citations in OpenAlex.

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  20. Microvascular thrombosis: experimental and clinical implications.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Krishna SriramDepartment of Mechanical and Aerospace Engineering, University of California, San Diego, California, USA.
Marcos Intaglietta
Daniel M Tartakovsky
University of California, San Diego · USLa Jolla Bioengineering Institute · US

Funding

Recombinant HbAp Production for In Vivo Toxicity StudiesP01HL110900 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FRIEDMAN, JOEL M · 2012 to 2016
$10.6M
NHLBI NIH HHS 5P01 HL110900NHLBI NIH HHS P01 HL110900
6 · The paper itself

Abstract

objectiveOur primary goal is to investigate the effects of non-Newtonian blood properties on wall shear stress in microvessels. The secondary goal is to derive a correction factor for the Poiseuille-law-based indirect measurements of wall shear stress.

methodsThe flow is assumed to exhibit two distinct, immiscible and homogeneous fluid layers: an inner region densely packed with RBCs, and an outer cell-free layer whose thickness depends on discharge hematocrit. The cell-free layer is assumed to be Newtonian, while rheology of the RBC-rich core is modeled using the Quemada constitutive law.

resultsOur model provides a realistic description of experimentally observed blood velocity profiles, tube hematocrit, core hematocrit, and apparent viscosity over a wide range of vessel radii and discharge hematocrits.

conclusionsOur analysis reveals the importance of incorporating this complex blood rheology into estimates of WSS in microvessels. The latter is accomplished by specifying a correction factor, which accounts for the deviation of blood flow from the Poiseuille law.

Indexed as

Computer SimulationHemorheologyModels, CardiovascularAlgorithmsArteriolesBlood Flow VelocityBlood ViscosityErythrocytesHematocritStress, Mechanicalapparent viscosityblood rheologyhematocritplasma layershear stressshear thinning

Identifiers

PMID24703006
PMCPMC4185264
OpenAlexW2119668725

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.