Evidence map›Paper›PMID 24702996›Full record

ArticleCell stem cell2014

Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study.

Sanggu Kim, Namshin Kim, Angela P Presson, Mark E Metzger, Aylin C Bonifacino, Mary Sehl, Samson A Chow, Gay M Crooks, Cynthia E Dunbar, Dong Sung An and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 105 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Mapping Hematopoietic Fate after Transplantation.Stem cell reviews and reports · 2025
    Review
  6. In vivo tracking of ex-vivo-generatedMolecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Sanggu KimDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Namshin KimKorean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong-gu, Daejeon 305-806, Korea.
Angela P PressonDepartment of Biostatistics, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Mark E MetzgerHematology Branch, National Heart, Lung and Blood Institute, NIH, Rockville, MD 20850, USA.
Aylin C BonifacinoHematology Branch, National Heart, Lung and Blood Institute, NIH, Rockville, MD 20850, USA.
Mary SehlDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Biomathematics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Samson A ChowDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Gay M CrooksDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cynthia E DunbarHematology Branch, National Heart, Lung and Blood Institute, NIH, Rockville, MD 20850, USA.
Dong Sung AnUCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; School of Nursing, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Robert E DonahueHematology Branch, National Heart, Lung and Blood Institute, NIH, Rockville, MD 20850, USA.
Irvin S Y ChenDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: syuchen@mednet.ucla.edu.
University of California, Los Angeles · USNational Heart Lung and Blood Institute · USBlack AIDS Institute · USKorea Research Institute of Bioscience and Biotechnology · KR

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
NHLBI Animal Program DivisionZIGHL006020 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CLARK, TANNIA · 2009 to 2025
$47.3M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
Retroviral Mediated Gene Transfer Into Primate Hematopoietic CellsZICHL002338 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DONAHUE, ROBERT E · 2010 to 2018
$30.5M
Optimization of gene transfer safety and efficacy focusing on the NHP modelZIAHL002339 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DUNBAR, CYNTHIA E · 2009 to 2025
$26.8M
Understanding hematopoietic stem cell mobilization and engraftmentZIAHL006063 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DUNBAR, CYNTHIA E · 2010 to 2025
$23.5M
Transduction of Human Stem and Progenitor CellsP01HL073104 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KOHN, DONALD B · 2003 to 2013
$18.3M
Novel therapies for bone marrow failure and Diamond-Blackfan AnemiaZIAHL006186 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DUNBAR, CYNTHIA E · 2014 to 2025
$5.7M
UCLA Clinical and Translational Science InstituteKL2TR000122 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$4.5M
MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATIONR01CA068859 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHOW, SAMSON A · 1995 to 2008
$2.5M
Modeling HIV-1 SiRNA TherapyR01AI055281 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, IRVIN S.Y. · 2003 to 2010
$2.3M
Defining a therapeutic threshold in HSPC gene therapy for HIV-1 diseaseR00HL116234 · NHLBI · OHIO STATE UNIVERSITY · PI KIM, SANGGU · 2016 to 2018
$747k
Intramural NIH HHSNCATS NIH HHS KL2 TR000122NCI NIH HHS CA68859NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA068859NHLBI NIH HHS K99 HL116234NHLBI NIH HHS P01 HL073104NHLBI NIH HHS R00 HL116234NIAID NIH HHS AI055281-06A2NIAID NIH HHS P30 AI028697NIAID NIH HHS R01 AI055281
6 · The paper itself

Abstract

In mice, clonal tracking of hematopoietic stem cells (HSCs) has revealed variations in repopulation characteristics. However, it is unclear whether similar properties apply in primates. Here, we examined this issue through tracking of thousands of hematopoietic stem and progenitor cells (HSPCs) in rhesus macaques for up to 12 years. Approximately half of the clones analyzed contributed to long-term repopulation (over 3-10 years), arising in sequential groups and likely representing self-renewing HSCs. The remainder contributed primarily for the first year. The long-lived clones could be further subdivided into functional groups contributing primarily to myeloid, lymphoid, or both myeloid and lymphoid lineages. Over time, the 4%-10% of clones with robust dual lineage contribution predominated in repopulation. HSPCs expressing a CCR5 shRNA transgene behaved similarly to controls. Our study therefore documents HSPC behavior in a clinically relevant model over a long time frame and provides a substantial system-level data set that is a reference point for future work.

Indexed as

Cell DifferentiationCell LineageCell TrackingAnimalsCells, CulturedGenetic VectorsHematopoietic Stem CellsLymphocytesMacaca mulattaMiceMyeloid CellsReceptors, CCR5RNA, Small InterferingTransgenesReceptors, CCR5RNA, Small Interfering

Identifiers

PMID24702996
PMCPMC4009343
OpenAlexW2053061573

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.