ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2014
Polymorphisms in inflammatory genes are associated with term small for gestational age and preeclampsia.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- From IL-6 production to IL-6R buffering: a unified IL-6-IL-6R framework for immune homeostasis during viral infection.Frontiers in immunology · 2026Review
- Comprehensive identification of immune-related biomarkers and therapeutic targets in preeclampsia: integrative bioinformatics and experimental validation.BMC pregnancy and childbirth · 2025Article
- Interleukin-6 (-174G/C), Interleukin-1β (-511 C/T), and Apolipoprotein B-100 (2488 C/T) Gene Polymorphism in Pre-Eclampsia.Medicina (Kaunas, Lithuania) · 2024Observational
- Polymorphisms within the Tumor Necrosis Factor-Alpha Gene Is Associated with Preeclampsia in Taiwanese Han Populations.Biomedicines · 2023Article
- Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome.Journal of pregnancy · 2022Review
- Genetic markers for preeclampsia in Peruvian women.Colombia medica (Cali, Colombia) · 2021Article
- Pregnancy complications recur independently of maternal vascular malperfusion lesions.PloS one · 2020Article
- Differential expression of T helper cytokines in the liver during early pregnancy in sheep.Animal reproduction · 2019Article
- Modulation of Helper T Cytokines in Thymus during Early Pregnancy in Ewes.Animals : an open access journal from MDPI · 2019Article
- Fetal-Not Maternal-APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry.American journal of human genetics · 2018Article
- Maternal Interleukin Genotypes Are Associated With NICU Outcomes Among Low-Birth-Weight Infants.Biological research for nursing · 2017Article
- CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia.Circulation research · 2016Article
- Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia.Scientific reports · 2016Article
- Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls.Pregnancy hypertension · 2016Article
- Berberine alleviates preeclampsia possibly by regulating the expression of interleukin-2/interleukin-10 and Bcl-2/Bax.International journal of clinical and experimental medicine · 2015Article
- Molecular association of pathogenetic contributors to pre-eclampsia (pre-eclampsia associome).BMC systems biology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
problemInflammatory biomarkers are associated with preeclampsia (PE) and poor fetal growth; however, genetic epidemiologic studies have been limited by reduced gene coverage and the exclusion of African American mothers. METHOD OF STUDY: Cases and controls (N = 1646) from a pregnancy cohort were genotyped for 503 tagSNPs in 40 genes related to inflammation. Gene-set analyses were stratified by race and were followed by a single SNP analysis within significant gene sets.
resultsGene-level associations were found for IL6 and KLRD1 for term small for gestational age (SGA) among African Americans. LTA/TNF and TBX21 were associated with PE among European Americans. The strongest association was for PE among European Americans for an upstream regulator of TNF with RR = 1.8 (95% CI 1.1-2.7).
conclusionAlthough previous studies have suggested null associations, increased tagging and stratification by genetic ancestry suggests important associations between IL6 and term SGA for African Americans, and a TNF regulator and PE among European Americans (N = 149).
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Registered trials
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