ArticleNeuropathology : official journal of the Japanese Society of Neuropathology2014
Coxsackievirus B4 myocarditis and meningoencephalitis in newborn twins.
Article in Neuropathology : official journal of the Japanese Society of Neuropathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Clinical characteristics of severe neonatal enterovirus infection: a systematic review.BMC pediatrics · 2021Pooled it
- Screening of a potential coxsackievirus B4 vaccine strain through analysis of biological features.Scientific reports · 2026Article
- Establishment of severe in vitro and in vivo infection models for coxsackievirus B4 and their application in identifying viral virulence determinants.Virologica Sinica · 2026Article
- Chemical Characterization and Evaluation of Antimicrobial, Antioxidant, and Synergistic Activities ofPharmaceutics · 2026Article
- Isolation and near-complete genome of human enterovirus B4 (Coxsackie virus B4) strain isolated from a nasopharyngeal swab of a 5-year-old male child with severe hand, foot, and mouth disease in Mizoram, India.Microbiology resource announcements · 2025Article
- Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes.Diabetologia · 2025Article
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- Nutraceutical potential of moroccanFrontiers in chemistry · 2025Article
- Immunogenicity and protective efficacy of inactivated coxsackievirus B4 viral particles.Emerging microbes & infections · 2024Article
- Identification of compounds fromSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes.medRxiv : the preprint server for health sciences · 2024Article
- Enteroviruses: epidemic potential, challenges and opportunities with vaccines.Journal of biomedical science · 2024Review
- Cardiovascular-related death in infancy and childhood: a clinicopathological study of two referral institutions in England.Forensic science, medicine, and pathology · 2024Article
- A Study of the Synergistic Effects of Essential Oils fromMetabolites · 2024Article
- Chemical composition, antimicrobial, and antioxidant properties of essential oils fromFrontiers in chemistry · 2024Article
- Analysis of the Chemical Composition and Evaluation of the Antioxidant, Antimicrobial, Anticoagulant, and Antidiabetic Properties ofBiomedicines · 2023Article
- Advancing Precision Medicine in Myocarditis: Current Status and Future Perspectives in Endomyocardial Biopsy-Based Diagnostics and Therapeutic Approaches.Journal of clinical medicine · 2023Review
- Identification of Compounds ofPharmaceuticals (Basel, Switzerland) · 2023Article
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- Phenolic Content, Antioxidant, Antibacterial, Antihyperglycemic, and α-Amylase Inhibitory Activities of Aqueous Extract ofPharmaceuticals (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Coxsackievirus B4 (CB4) is a picornavirus associated with a variety of human diseases, including neonatal meningoencephalitis, myocarditis and type 1 diabetes. We report the pathological findings in twin newborns who died during an acute infection. The twins were born 1 month premature but were well and neurologically intact at birth. After a week they developed acute lethal neonatal sepsis and seizures. Histopathology demonstrated meningoencephalitis and severe myocarditis, as well as pancreatitis, adrenal medullitis and nephritis. Abundant CB4 sequences were identified in nucleic acid extracted from the brain and heart. In situ hybridization with probes to CB4 demonstrated infection of neurons, myocardiocytes, endocrine pancreas and adrenal medulla. The distribution of infected cells and immune response is consistent with reported clinical symptomatology where systemic and neurological diseases are the result of CB4 infection of select target cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.