ArticleRadiation research2014
Focal therapeutic irradiation induces an early transient increase in bone glycation.
Article in Radiation research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Dose-dependent effects of gamma radiation sterilization on the collagen matrix of human cortical bone allograft and its influence on fatigue crack propagation resistance.Cell and tissue banking · 2024Article
- Secretory factors released from high dose radiation-activated osteoclasts increase the expression level of pain-associated neuropeptides in sensory neuronal cultures.Research square · 2024Article
- Pilot Study: Short Term Impact of Radiation Therapy on Bone Mineral Density and Bone Metabolism.Calcified tissue international · 2023Article
- The effects of BPA-BNCT on normal bone: determination of the CBE value in mice‡.Journal of radiation research · 2023Article
- Relative Effects of Radiation-Induced Changes in Bone Mass, Structure, and Tissue Material on Vertebral Strength in a Rat Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Relations Between Bone Quantity, Microarchitecture, and Collagen Cross-links on Mechanics Following In Vivo Irradiation in Mice.JBMR plus · 2021Article
- Altered mechanical behavior of demineralized bone following therapeutic radiation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Radiation-induced changes to bone composition extend beyond periosteal bone.Bone reports · 2020Article
- Limited field radiation therapy results in decreased bone fracture toughness in a murine model.PloS one · 2018Article
- Longitudinal Effects of Single Hindlimb Radiation Therapy on Bone Strength and Morphology at Local and Contralateral Sites.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Parathyroid Hormone (1-34) Transiently Protects Against Radiation-Induced Bone Fragility.Calcified tissue international · 2016Article
- Article
- Long-term loss of osteoclasts and unopposed cortical mineral apposition following limited field irradiation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- CORR Insights®: do long term survivors of ewing family of tumors experience low bone mineral density and increased fracture risk?Clinical orthopaedics and related research · 2014Article
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Authors and funding
2 authors.
Funding
Abstract
Advanced glycation end products (AGEs) are an abnormal modification of the collagenous matrix in bone, and their accumulation contributes to alteration of mechanical properties. Using a mouse model of focal external radiotherapy, we quantified the time-dependent changes in the glycation of bone collagen after 4 daily fractions of 5 Gy exposure to unilateral hindlimb. Fluorometric analysis of decalcified femurs demonstrated a significant and transient increase in the quantity of pentosidine, pyridinolines and nonspecific AGEs per unit of collagen at one week postirradiation. These differences did not persist at 4, 8, 12 or 26 weeks postirradiation. Radiation had no effect on bone collagen content. We hypothesize that following the transient increase in glycation products, these crosslinks are then removed as a result of increased postirradiation osteoclast activity and continued mineralization of the bone.
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