ArticleBioMed research international2014
Helminth infection increases the probability of indeterminate QuantiFERON gold in tube results in pregnant women.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Latent Tuberculosis in Pregnancy: A Systematic Review.PloS one · 2016Pooled it
- Mycobacterium tuberculosis infection in pregnancy: A systematic review.PLOS global public health · 2024Article
- Magnitude and predisposing factors of intestinal parasitosis and tuberculosis coinfection at five health institutions in Southern Ethiopia: A cross-sectional study.Health science reports · 2023Article
- The Global Prevalence ofTropical medicine and infectious disease · 2022Review
- Retrospective Performance Analyses of over Two Million U.S. QuantiFERON Blood Sample Results.Microbiology spectrum · 2021Article
- Prevalence of Schistosoma mansoni infection in Ethiopia: a systematic review and meta-analysis.Tropical diseases, travel medicine and vaccines · 2021Review
- Magnitude of parasitic infections and associated factors among pregnant women at health facilities in Hawassa, Southern Ethiopia.F1000Research · 2021Article
- Interactions between helminths and tuberculosis infections: Implications for tuberculosis diagnosis and vaccination in Africa.PLoS neglected tropical diseases · 2020Review
- Risk Factors for False-Negative Interferon-γ Release Assay Results in Culture-Confirmed Childhood TB.The American journal of tropical medicine and hygiene · 2019Article
- Intestinal parasites co-infection and associated factors among active pulmonary tuberculosis patients in selected health centers, Addis Ababa, Ethiopia: unmatched case control study.BMC infectious diseases · 2019Article
- Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection.Frontiers in immunology · 2018Observational
- Article
- Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania.PLoS neglected tropical diseases · 2017Article
- Helminth-Tuberculosis Co-infection: An Immunologic Perspective.Trends in immunology · 2016Review
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4 authors at 3 institutions in 1 country.
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Abstract
backgroundApproximately one-third of the world population is infected with M. tuberculosis and helminths (Kariminia et al. (2009), Walson et al. (2010)). Pregnancy and Helminth infection are known to suppress the TH1 response (Kariminia et al. (2009), Elias et al. (2006)) on which the QuantiFERON Gold in Tube (QFT-GIT) assay, that measures the released IFN-γ upon in vitro stimulation with mycobacterial antigens, relies on (Thomas et al. (2010)).
objectiveTo determine whether QFT-GIT indeterminate result is significantly associated with helminth infection or not.
methodsIn this cross-sectional study, eighty-five pregnant mothers were screened for parasitic and LTBI using Kato-Katz and QFT-GIT test-respectively,
resultThe prevalence of helminth infection in pregnant mothers was 23 (27%) of this 17 (20%) was due to Schistosoma mansoni. Among the total of 85 study participants 26.8% were QFT-GIT positive and 14 (17%) had indeterminate results. Three samples (21.4%) were randomly selected from the indeterminate QFT-GIT results and retested to check the reproducibility of the assay and remained indeterminate. QFT-GIT indeterminate result showed significant association with helminth infection.
conclusionHelminth infections were significantly associated with indeterminate QFT-GIT results in pregnant mothers. Therefore further study is important to evaluate the possible effect of helminth infection by excluding the effect of pregnancy, as pregnancy also downregulates cellular immunity.
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