Evidence map›Paper›PMID 24701540›Full record

ArticleJournal of clinical and diagnostic research : JCDR2014

Transepithelial Brush Biopsy - Oral CDx® - A Noninvasive Method for the Early Detection of Precancerous and Cancerous Lesions.

Casparis S, Borm J M, Tomic M A, Burkhardt A, Locher M C

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In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
  2. A brief review of cytology in dentistry.British dental journal · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Casparis SFaculty, Oral Surgery, Center of Dental Medicine, University of Zurich , Switzerland .
Borm J MFaculty, Oral Surgery, Center of Dental Medicine, University of Zurich , Switzerland .
Tomic M AFaculty, Oral Surgery, Center of Dental Medicine, University of Zurich , Switzerland .
Burkhardt AFaculty, Institute of Pathology , Reutlingen, Germany .
Locher M CFaculty, Oral Surgery, Center of Dental Medicine, University of Zurich , Switzerland .

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Oral CDx® brush biopsy (BB) method is a computer-assisted sample analysis that detects abnormal cells in all cell layers of the epithelium of the oral mucosa.

methodWe took 263 oral BBs from 200 patients with potentially malignant disorders.

resultsWe received 204 negative results and 39 atypical, 7 positive and 13 inadequate results. SBs were taken in 56 cases. Therefore, the sensitivity for the detection of abnormal cells was 90% and the specificity was 44.1%. The positive predictive value accounted for 47.2% and the NPV accounted for 88.2%. DISCUSSION AND

conclusionFor the results of sensitivity and specificity of the Oral CDx® BB, there is still space for improvement but they are already high. Additional methods like DNA-image cytometry may enhance the results. But it is a simple and noninvasive method which does not need a special effort either from the patient or from the clinicians.

Indexed as

Brush biopsyMucosal lesionsOral cancerScreening methodSensitivitySpecificity

Identifiers

PMID24701540
PMCPMC3972569

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.