Evidence map›Paper›PMID 24701436›Full record

ArticleIndian journal of endocrinology and metabolism2014

Vitamin D and insulin resistance in postmenopausal Indian women.

Niti Agarwal, Ambrish Mithal, Parjeet Kaur, Vibha Dhingra, M M Godbole, M Shukla

Open access · diamondAbstract read
In one paragraph

Article in Indian journal of endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Association of Hypovitaminosis D with Metabolic Syndrome in Postmenopausal Women.Journal of obstetrics and gynaecology of India · 2020
    Review
  6. Vitamin D Status and Cardio-Metabolic Risk in Indian Postmenopausal Women.Journal of clinical and diagnostic research : JCDR · 2016
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Niti AgarwalApollo Centre for Obesity, Diabetes and Endocrinology, IP Apollo Hospital, Sarita Vihar, New Delhi, India.
Ambrish MithalDivision of Endocrinology and Diabetes, Medanta, The Medicity, Gurgaon, Haryana, India.
Parjeet KaurDivision of Endocrinology and Diabetes, Medanta, The Medicity, Gurgaon, Haryana, India.
Vibha DhingraApollo Centre for Obesity, Diabetes and Endocrinology, IP Apollo Hospital, Sarita Vihar, New Delhi, India.
M M GodboleDepartment of Endocrinology, Sanjay Gandhi Post Graduate Institute, Lucknow, Uttar Pradesh, India.
M ShuklaDepartment of Endocrinology, Sanjay Gandhi Post Graduate Institute, Lucknow, Uttar Pradesh, India.
Apollo Hospitals · INMedanta The Medicity · INSanjay Gandhi Post Graduate Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study is to investigate the association of the serum 25-hydroxyvitamin D (25-OHD) level with markers of insulin resistance (IR) in postmenopausal Indian women. MATERIALS AND

methodsThis was a cross-sectional study, conducted at a Tertiary Care Hospital in New Delhi, India. Seventy one postmenopausal women (mean age 56.3 ± 7.6 years) were enrolled. Exclusion criteria were known or newly detected diabetics, subjects with chronic renal failure, chronic liver disease or any other chronic inflammatory condition, chronic smokers and chronic alcoholics. Serum calcium (and albumin for calculating corrected calcium), phosphorus, alkaline phosphatase and 25-OHD were measured as parameters of calcium homeostasis. Fasting blood glucose (FBG), systolic and diastolic blood pressures, body mass index (BMI), fasting serum insulin, calculated glucose insulin ratio (GIR), and homeostatic model assessment of insulin resistance (HOMA-IR) were studied as parameters of IR. Data was then analyzed for statistical significance.

resultsThe mean serum 25-OHD level was 12.73 ± 7.63 ng/ml. The mean BMI was 27.78 ± 5.37 kg/m(2). The mean calculated GIR was 13.14 ± 9.39 and HOMA-IR was 2.31 ± 1.70. Serum 25-OHD was inversely correlated with BMI (correlation coefficient -0.234, P value 0.050) and with HOMA-IR (correlation coefficient -0.237, P value 0.047). However, when 25-OHD was adjusted for BMI the correlation between 25-OHD and HOMA-IR lost its significance. No correlation was found between serum 25-OHD and any other parameters of IR studied.

conclusionsThere is a significant negative linear correlation between 25-OHD and BMI. The significant negative linear correlation between 25-OHD and HOMA-IR was confounded by BMI. There is no correlation between 25-OHD and parameters of IR.

Indexed as

25-hydroxy vitamin D3Body mass indexhomeostatic model assessment of insulin resistancepostmenopausal women

Identifiers

PMID24701436
PMCPMC3968740
OpenAlexW2000224465

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.