ArticleArchives of medical science : AMS2014
Association of dental and periodontal status with bisphosphonate-related osteonecrosis of the jaws. A retrospective case controlled study.
Article in Archives of medical science : AMS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Association between periodontal disease severity and the risk of medication-related osteonecrosis of the jaw: a systematic review and meta-analysis by the Korean Academy of Periodontology.Journal of periodontal & implant science · 2026Review
- Article
- Oral Health-Related Quality of Life and Mental Health Impairment in Patients Affected by Medication-Related Osteonecrosis of the Jaws: A Case-Control Pilot Study.Dentistry journal · 2023Article
- A Study of Oral Health Parameters and the Properties and Composition of Saliva in Oncological Patients with and without Medication-Related Osteonecrosis of the Jaw Who Take Bisphosphonates.Medicina (Kaunas, Lithuania) · 2023Article
- Potential Relationship between Poor Oral Hygiene and MRONJ: An Observational Retrospective Study.International journal of environmental research and public health · 2023Observational
- Composition and Properties of Saliva in Patients with Osteoporosis Taking Antiresorptive Drugs.International journal of environmental research and public health · 2023Article
- Organic Bone Matrix Component Type I and V Collagen Are Not Destructed in Bisphosphonate-Associated Osteonecrosis of the Jaws.Medicina (Kaunas, Lithuania) · 2022Article
- Inhibition of HMGB1/RAGE Signaling Reduces the Incidence of Medication-Related Osteonecrosis of the Jaw (MRONJ) in Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Oral health condition in cancer patients under bisphosphonate therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Osteonecrosis of the jaw induced by treatment with anti-PD-1 immunotherapy: a case report.Immunotherapy · 2020Article
- A new anabolic compound, LLP2A-Ale, reserves periodontal bone loss in mice through augmentation of bone formation.BMC pharmacology & toxicology · 2020Article
- Exposed necrotic bone in 183 patients with bisphosphonate-related osteonecrosis of the jaw: Associated clinical characteristics.Medicina oral, patologia oral y cirugia bucal · 2017Article
- A 5-year retrospective longitudinal study on the incidence and the risk factors of osteonecrosis of the jaws in patients treated with zoledronic acid for bone metastases from solid tumors.Medicina oral, patologia oral y cirugia bucal · 2017Article
- Radiographic evidence of treatment with bisphosphonates.British dental journal · 2017Article
- Effect of a local, one time, low-dose injection of zoledronic acid on titanium implant osseointegration in ovariectomized rats.Archives of medical science : AMS · 2016Article
- Incidence and risk predictors for osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates.Archives of medical science : AMS · 2015Article
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Abstract
introductionTo assess the association of oral hygiene, dental caries, and periodontal status with bisphosphonate-related osteonecrosis of the jaws. MATERIAL AND
methodsA retrospective case-control study on 81 patients treated for neoplasms with bone metastases. Twenty-nine patients with bone necrosis and 52 controls treated with bisphosphonates were compared using the Oral Hygiene Index, Decay, Missing, Filled Teeth, Community Periodontal Index of Treatment Needs, and Residual Periodontal Bone. The null hypothesis stated that there was no difference in parameters of oral health between patients with and without bone necrosis. Differences of means of above-mentioned variables were compared between the groups with Student's t-test or Mann-Whitney rank sum test and χ(2) test. Value of p ≤ 0.05 was considered significant.
resultsPoorer oral hygiene (OHIs 1.94 vs. 1.32; p = 0.065), more advanced dental caries (DMFT 26.85 vs. 22.87; p = 0.05), and more advanced periodontal disease (CPITN: = 0: 21.05% vs. 42.51%; = 1 13.16% vs. 7.29%; = 2: 0% vs. 15.38%; = 3: 65.79% vs. 28.34%; = 4: 0% vs. 6.48%, Residual periodontal bone 73.1% vs. 80.51%; p = 0,001) were characteristic of patients with bisphosphonate related jaw necrosis when compared with control group. An advanced dental caries or periodontal disease required surgical intervention which directly contributed to the development of the bone necrosis.
conclusionsDental and periodontal disease can lead to bisphosphonate-related osteonecrosis of the jaw. Oncologic patients treated with bisphosphonates should be offered preventive care to reduce dental plaque, calculus, dental caries, and periodontal disease.
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