Evidence map›Paper›PMID 24700875›Full record

ArticleJournal of the American Society of Nephrology : JASN2014

Evidence for anti-inflammatory effects of exercise in CKD.

João L Viana, George C Kosmadakis, Emma L Watson, Alan Bevington, John Feehally, Nicolette C Bishop, Alice C Smith

3 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 89 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 11 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03064555 completednot on this mapstarted 2017, after this paper: background citation

Acute Physiological Response to Exercise in End Stage Renal Disease

Typeobservational_patient_registrySponsorCoventry UniversityRan2017 to 2019Enrolled40ConditionsRenal Disease
NCT05241652 nacompletednot on this mapstarted 2022, after this paper: background citation

Strong Point of Inspiratory Muscle Training for Kidney and Immune Functions, and Quality of Life of Chronic Kidney Disease Patients on Hemodialysis

TypeinterventionalSponsorUniversitas PadjadjaranRan2022 to 2022Enrolled32ConditionsChronic Kidney Disease Stage 5 on DialysisArmsInspiratory Muscle Training with an intensity of 50% MIP, Inspiratory Muscle Training with an intensity of 10% MIP
NCT06669702 narecruitingnot on this mapstarted 2024, after this paper: background citation

EXercise As an Anti-inflammatory Treatment in Axial Spondyloarthritis (axSpA) for Patients Taking Biologic Therapy: a Proof of Concept Study (ExTASI-B).

TypeinterventionalSponsorLoughborough UniversityRan2024 to 2029Enrolled60ConditionsAxial Spondyloarthrithis, Inflammatory Diseases, ArthritisArms12-week home based exercise, Routine care
3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 11 syntheses or guidelines pooled it, 191 citations in OpenAlex.

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  4. Cognitive Impairment in End Stage Renal Disease Patients Undergoing Hemodialysis: Markers and Risk Factors.International journal of environmental research and public health · 2022
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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

João L VianaSchool of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, United Kingdom; j.viana@lboro.ac.uk.
George C KosmadakisJohn Walls Renal Unit, Leicester General Hospital, Leicester, United Kingdom; and.
Emma L WatsonDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Alan BevingtonDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
John FeehallyJohn Walls Renal Unit, Leicester General Hospital, Leicester, United Kingdom; and.
Nicolette C BishopSchool of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, United Kingdom;
Alice C SmithJohn Walls Renal Unit, Leicester General Hospital, Leicester, United Kingdom; and Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Leicester General Hospital · GBUniversity of Leicester · GBEnglish Institute of Sport · GBLoughborough University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CKD is associated with a complex state of immune dysfunction characterized by immune depression, predisposing patients to infections, and immune activation, resulting in inflammation that associates with higher risk of cardiovascular disease. Physical exercise may enhance immune function and exert anti-inflammatory effects, but such effects are unclear in CKD. We investigated the separate effects of acute and regular moderate-intensity aerobic exercise on neutrophil degranulation (elastase release), activation of T lymphocytes (CD69 expression) and monocytes (CD86 and HLA-DR expression), and plasma inflammatory markers (IL-6, IL-10, soluble TNF-receptors, and C-reactive protein) in patients with predialysis CKD. A single 30-minute (acute) bout of walking induced a normal pattern of leukocyte mobilization and had no effect on T-lymphocyte and monocyte activation but improved neutrophil responsiveness to a bacterial challenge in the postexercise period. Furthermore, acute exercise induced a systemic anti-inflammatory environment, evidenced by a marked increase in plasma IL-10 levels (peaked at 1 hour postexercise), that was most likely mediated by increased plasma IL-6 levels (peaked immediately postexercise). Six months of regular walking exercise (30 min/d for 5 times/wk) exerted anti-inflammatory effects (reduction in the ratio of plasma IL-6 to IL-10 levels) and a downregulation of T-lymphocyte and monocyte activation, but it had no effect on circulating immune cell numbers or neutrophil degranulation responses. Renal function, proteinuria, and BP were also unaffected. These findings provide compelling evidence that walking exercise is safe with regard to immune and inflammatory responses and has the potential to be an effective anti-inflammatory therapy in predialysis CKD.

Indexed as

AgedC-Reactive ProteinExerciseExercise TherapyFemaleHumansInflammationInflammation MediatorsInterleukin-10Interleukin-6Lymphocyte ActivationMaleMiddle AgedMonocytesNeutrophil ActivationReceptors, Tumor Necrosis Factor, Type IC-Reactive ProteinIL10 protein, humanIL6 protein, humanInflammation MediatorsInterleukin-10Interleukin-6Receptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type II

Identifiers

PMID24700875
PMCPMC4147973
OpenAlexW2119156683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.