ArticleDevelopment (Cambridge, England)2014
Specification of regional intestinal stem cell identity during Drosophila metamorphosis.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage ineLife · 2026Article
- Stem cell-specific NF-κB is required for stem cell survival and epithelial regeneration upon intestinal damage.Biology open · 2025Article
- Article
- A whole-body atlas of BMP signaling activity in an adult sea anemone.BMC biology · 2025Article
- Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.Nature cell biology · 2024Article
- Monitoring Gut Acidification in the Adult Drosophila Intestine.Journal of visualized experiments : JoVE · 2021Article
- Model systems for regeneration:Development (Cambridge, England) · 2020Review
- Defective Proventriculus Regulates Cell Specification in the Gastric Region ofFrontiers in physiology · 2020Article
- AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis.Nature communications · 2019Article
- Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- Anatomy and Physiology of the Digestive Tract ofGenetics · 2018Review
- Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective.Journal of developmental biology · 2018Review
- Hippo, TGF-β, and Src-MAPK pathways regulate transcription of the upd3 cytokine in Drosophila enterocytes upon bacterial infection.PLoS genetics · 2017Article
- Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.Cell stem cell · 2017Article
- Ubx dynamically regulates Dpp signaling by repressing Dad expression during copper cell regeneration in the adult Drosophila midgut.Developmental biology · 2016Article
- Maintenance of the adult Drosophila intestine: all roads lead to homeostasis.Current opinion in genetics & development · 2016Review
- Gastrointestinal stem cells in health and disease: from flies to humans.Disease models & mechanisms · 2016Review
- mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Exploring the physiology and pathology of aging in the intestine ofInvertebrate reproduction & development · 2015Article
- Article
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Authors and funding
2 authors.
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Abstract
In the adult Drosophila midgut the bone morphogenetic protein (BMP) signaling pathway is required to specify and maintain the acid-secreting region of the midgut known as the copper cell region (CCR). BMP signaling is also involved in the modulation of intestinal stem cell (ISC) proliferation in response to injury. How ISCs are able to respond to the same signaling pathway in a regionally different manner is currently unknown. Here, we show that dual use of the BMP signaling pathway in the midgut is possible because BMP signals are only capable of transforming ISC and enterocyte identity during a defined window of metamorphosis. ISC heterogeneity is established prior to adulthood and then maintained in cooperation with regional signals from surrounding tissue. Our data provide a conceptual framework for how other tissues maintained by regional stem cells might be patterned and establishes the pupal and adult midgut as a novel genetic platform for identifying genes necessary for regional stem cell specification and maintenance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.