ArticleContrast media & molecular imaging
The reciprocal linear QUEST analysis method facilitates the measurements of chemical exchange rates with CEST MRI.
Article in Contrast media & molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Motion and magnetic field inhomogeneity correction techniques for chemical exchange saturation transfer (CEST) MRI: A contemporary review.NMR in biomedicine · 2025Review
- Induced saturation transfer recovery steady states (iSTRESS) for proton exchange rate mapping with CEST MRI, a preliminary study.Magnetic resonance imaging · 2024Article
- Validation of the presence of fast exchanging amine CEST effect at low saturation powers and its influence on the quantification of APT.Magnetic resonance in medicine · 2023Article
- Detection of tissue pH with quantitative chemical exchange saturation transfer magnetic resonance imaging.NMR in biomedicine · 2023Review
- An end-to-end LSTM-Attention based framework for quasi-steady-state CEST prediction.Frontiers in neuroscience · 2023Article
- Label-Free Assessment of Mannitol Accumulation Following Osmotic Blood-Brain Barrier Opening Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging.Pharmaceutics · 2022Article
- TowardBiosensors · 2022Review
- Development of a Nanoscale Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agent That Measures pH.ACS nano · 2021Article
- Quasi-steady-state CEST (QUASS CEST) solution improves the accuracy of CEST quantification: QUASS CEST MRI-based omega plot analysis.Magnetic resonance in medicine · 2021Article
- Detection of Enzyme Activity and Inhibition during Studies in Solution, In Vitro and In Vivo with CatalyCEST MRI.Molecular imaging and biology · 2018Article
- Detecting in vivo urokinase plasminogen activator activity with a catalyCEST MRI contrast agent.NMR in biomedicine · 2017Article
- Noninvasive detection of enzyme activity in tumor models of human ovarian cancer using catalyCEST MRI.Magnetic resonance in medicine · 2017Article
- Diamagnetic Imaging Agents with a Modular Chemical Design for Quantitative Detection of β-Galactosidase and β-Glucuronidase Activities with CatalyCEST MRI.Bioconjugate chemistry · 2016Article
- Detection of Sulfatase Enzyme Activity with a CatalyCEST MRI Contrast Agent.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Screening CEST contrast agents using ultrafast CEST imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2016Article
- Design and optimization of pulsed Chemical Exchange Saturation Transfer MRI using a multiobjective genetic algorithm.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2016Article
- A comparison of iopromide and iopamidol, two acidoCEST MRI contrast media that measure tumor extracellular pH.Contrast media & molecular imagingArticle
- A single diamagnetic catalyCEST MRI contrast agent that detects cathepsin B enzyme activity by using a ratio of two CEST signals.Contrast media & molecular imagingArticle
- A review of optimization and quantification techniques for chemical exchange saturation transfer MRI toward sensitive in vivo imaging.Contrast media & molecular imagingReview
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3 authors.
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Abstract
Magnetic resonance imaging (MRI) contrast media that are detected via chemical exchange saturation transfer (CEST) often require an accurate estimation of their chemical exchange rate, kex . A variety of analysis methods have been proposed to estimate kex , including the nonlinear QUEST analysis method that evaluates the CEST amplitude as a function of saturation time. We have derived a linear version of QUEST, termed the Reciprocal Linear QUEST (RL-QUEST) method. Our simulations and experimental results show that RL-QUEST performs as well as QUEST, while providing a more simplistic fitting procedure. Although CEST results should be acquired with saturation power that has a nutation rate that is faster than kex of the CEST agent, an exact determination of the saturation power is not required to accurately estimate kex with RL-QUEST. This new analysis method requires a determination of the CEST agent's concentration, which is straightforward for the analysis of CEST agents in chemical solutions, but may be a limitation during in vivo CEST MRI studies. Based on the results of this study and previous studies, we provide recommendations for the linear analysis method that should be employed for each type of CEST MRI study.
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