ArticleJournal of biophotonics2015
Optical Thromboelastography to evaluate whole blood coagulation.
Article in Journal of biophotonics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Assessing the micromechanical architecture of joint tissues with speckle rheological microscopy.Nature communications · 2026Article
- Laser speckle rheological microscopy reveals wideband viscoelastic spectra of biological tissues.Science advances · 2024Article
- Review
- Evaluation of Blood Coagulation by Optical Vortex Tracking.Sensors (Basel, Switzerland) · 2022Article
- Passive high-frequency microrheology of blood.Soft matter · 2022Article
- Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices.Journal of clinical medicine · 2022Review
- Mapping Mechanical Properties of the Tumor Microenvironment by Laser Speckle Rheological Microscopy.Cancer research · 2021Article
- In-vivo mechanical characterization of coronary atherosclerotic plaques in living swine using intravascular laser speckle imaging.Biomedical optics express · 2021Article
- Comprehensive Blood Coagulation Profiling in Patients Using iCoagLab: Comparison Against Thromboelastography.Thrombosis and haemostasis · 2020Article
- Tutorial on laser speckle rheology: technology, applications, and opportunities.Journal of biomedical optics · 2020Review
- Flow Rate and Raspberry Pi-based Paper Microfluidic Blood Coagulation Assay Device.IEEE sensors journal · 2019Article
- Comprehensive Coagulation Profiling at the Point-of-Care Using a Novel Laser-Based Approach.Seminars in thrombosis and hemostasis · 2019Article
- Optimizing transfusion strategies in damage control resuscitation: current insights.Journal of blood medicine · 2018Review
- Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor.Scientific reports · 2017Article
- Evaluating platelet aggregation dynamics from laser speckle fluctuations.Biomedical optics express · 2017Article
- Intraluminal laser speckle rheology using an omni-directional viewing catheter.Biomedical optics express · 2017Article
- Optical sensing of anticoagulation status: Towards point-of-care coagulation testing.PloS one · 2017Article
- Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds.Scientific reports · 2016Article
- Estimation of particle size variations for laser speckle rheology of materials.Optics letters · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Measurement of blood viscoelasticity during clotting provides a direct metric of haemostatic conditions. Therefore, technologies that quantify blood viscoelasticity at the point-of-care are invaluable for diagnosing coagulopathies. We present a new approach, Optical Thromboelastography (OTEG) that measures the viscoelastic properties of coagulating blood by evaluating temporal laser speckle fluctuations, reflected from a few blood drops. During coagulation, platelet-fibrin clot formation restricts the mean square displacements (MSD) of scatterers and decelerates speckle fluctuations. Cross-correlation analysis of speckle frames provides the speckle intensity temporal autocorrelation, g2 (t), from which MSD is deduced and the viscoelastic modulus of blood is estimated. Our results demonstrate a close correspondence between blood viscoelasticity evaluated by OTEG and mechanical rheometry. Spatio-temporal speckle analyses yield 2-dimensional maps of clot viscoelasticity, enabling the identification of micro-clot formation at distinct rates in normal and coagulopathic specimens. These findings confirm the unique capability of OTEG for the rapid evaluation of patients' coagulation status and highlight the potential for point-of-care use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.