ArticleHuman brain mapping2014
Longitudinal MRI reveals impaired cortical thinning in children and adolescents prenatally exposed to alcohol.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Persistent Alterations of Brain and Behavior in Children With Low Prenatal Alcohol Exposure.Biological psychiatry global open science · 2026Article
- Linking pregnancy- and birth-related risk factors to a multivariate fusion of child cortical structure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Linking Pregnancy- and Birth-Related Risk Factors to a Multivariate Fusion of Child Cortical Structure.bioRxiv : the preprint server for biology · 2025Article
- Prenatal alcohol exposure alters brain structure and neurocognitive outcomes for 6- to 7-year-old children in a South African birth cohort.Alcohol, clinical & experimental research · 2025Article
- Fetal Alcohol Spectrum Disorders.Current topics in behavioral neurosciences · 2025Review
- Structural and functional alterations in the contralateral hemisphere following pediatric intracranial surgery: a pilot longitudinal neuroimaging study.Frontiers in human neuroscience · 2025Article
- Association of in utero HIV exposure with child brain structure and language development: a South African birth cohort study.BMC medicine · 2024Article
- Associations Between Family History of Alcohol and/or Substance Use Problems and Frontal Cortical Development From 9 to 13 Years of Age: A Longitudinal Analysis of the ABCD Study.Biological psychiatry global open science · 2024Article
- Magnetic resonance elastography captures a transient benefit of exercise intervention on forebrain stiffness in a rat model of fetal alcohol spectrum disorders.Alcohol, clinical & experimental research · 2024Article
- Brain Volume in Fetal Alcohol Spectrum Disorders Over a 20-Year Span.JAMA network open · 2023Article
- Profiles of language and communication abilities in adolescents with fetal alcohol spectrum disorders.Journal of the International Neuropsychological Society : JINS · 2023Article
- Enhancing fetal alcohol spectrum disorders diagnosis with a classifier based on the intracerebellar gradient of volumetric undersizing.Human brain mapping · 2023Article
- Delayed cortical thinning in children and adolescents with prenatal alcohol exposure.Alcohol, clinical & experimental research · 2023Article
- Brain structural differences in children with fetal alcohol spectrum disorder and its subtypes.Frontiers in neuroscience · 2023Article
- Mapping corpus callosum surface reduction in fetal alcohol spectrum disorders with sulci and connectivity-based parcellation.Frontiers in neuroscience · 2023Article
- Article
- Neurodevelopmental Trajectories Following Prenatal Alcohol Exposure.Frontiers in human neuroscience · 2021Article
- Cross-Sectional Analysis of Spatial Working Memory Development in Children with Histories of Heavy Prenatal Alcohol Exposure.Alcoholism, clinical and experimental research · 2021Article
- Current Socioeconomic Status Correlates With Brain Volumes in Healthy Children and Adolescents but Not in Children With Prenatal Alcohol Exposure.Frontiers in human neuroscience · 2020Article
- The Standardization of Diagnostic Criteria for Fetal Alcohol Spectrum Disorder (FASD): Implications for Research, Clinical Practice and Population Health.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Brain imaging studies suggest that cortical thickness decreases during childhood and adolescence, in concert with underlying structural and synaptic changes required for cognitive maturation and regional specialization of function. Abnormalities of this protracted developmental process may provide key insights into the cognitive and behavioral deficits that emerge in individuals with fetal alcohol spectrum disorders (FASD). Several studies have demonstrated cortical thickness differences in children and adolescents who were prenatally exposed to alcohol, though all have been cross sectional, limiting conclusions about cortical development with age. In this study, we analyze serially collected T1 -weighted MRI from 11 children with FASD and 21 controls, scanned twice each ∼2 to 4 years apart. Mixed-models analysis of cortical thickness measurements revealed age-by-group interactions in cortical thinning, with FASD participants undergoing less developmental thinning than controls across many regions of the cortex, particularly in medial frontal and parietal areas. These results provide further longitudinal evidence in humans that prenatal alcohol exposure is associated with altered patterns of brain development that persist during childhood and adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.