Trial reportClinical autonomic research : official journal of the Clinical Autonomic Research Society2014
Normothermic central hypovolemia tolerance reflects hyperthermic tolerance.
Trial report in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans.Prehospital emergency care · 2023Trial
- Low-dose morphine reduces tolerance to central hypovolemia in healthy adults without affecting muscle sympathetic outflow.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- Hemodynamic Stability to Surface Warming and Cooling During Sustained and Continuous Simulated Hemorrhage in Humans.Shock (Augusta, Ga.) · 2016Trial
- Tissue oxygen saturation during hyperthermic progressive central hypovolemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Trial
- Heat Adaptation in Military Personnel: Mitigating Risk, Maximizing Performance.Frontiers in physiology · 2019Review
- Tolerance to a haemorrhagic challenge during heat stress is improved with inspiratory resistance breathing.Experimental physiology · 2018Article
- Plasma hyperosmolality improves tolerance to combined heat stress and central hypovolemia in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- The Effect of Passive Heat Stress and Exercise-Induced Dehydration on the Compensatory Reserve During Simulated Hemorrhage.Shock (Augusta, Ga.) · 2016Article
- Mechanisms of orthostatic intolerance during heat stress.Autonomic neuroscience : basic & clinical · 2016Review
- Fluid restriction during exercise in the heat reduces tolerance to progressive central hypovolaemia.Experimental physiology · 2015Article
- Human cardiovascular responses to passive heat stress.Comprehensive Physiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purposeTo test the hypothesis that those who are highly tolerant to lower body negative pressure (LBNP) while normothermic are also highly tolerant to this challenge while hyperthermic.
methodsSixty pairs of normothermic and hyperthermic LBNP tests to pre-syncope were evaluated. LBNP tolerance was quantified via the cumulative stress index (CSI), which is calculated as the sum of the product of the LBNP level and the duration of each level until test termination (i.e., 20 mmHg × 3 min + 30 mmHg × 3 min, etc.). CSI was compared between normothermic and hyperthermic trials. Internal and skin temperatures, heart rate, and arterial pressure were measured throughout.
resultsHyperthermia reduced (P < 0.001) CSI from 997 ± 437 to 303 ± 213 mmHg min. There was a positive correlation between normothermic and hyperthermic LBNP tolerance (R (2) = 0.38; P < 0.001). As a secondary analysis, the 20 trials with the highest LBNP tolerance while normothermic were identified (indicated as the HIGH group; CSI 1,467 ± 356 mmHg min), as were the 20 trials with the lowest normothermic tolerance (indicated as the LOW group; CSI 565 ± 166 mmHg min; P < 0.001 between groups). While hyperthermia unanimously reduced CSI in both HIGH and LOW groups, in this hyperthermic condition CSI was ~threefold higher in the HIGH group (474 ± 226 mmHg min) relative to the LOW group (160 ± 115 mmHg min; P < 0.001).
conclusionsLBNP tolerance while hyperthermic is related to normothermic tolerance and, associated with this finding, those who have a high LBNP tolerance while normothermic remain relatively tolerant when hyperthermic.
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