ArticlePloS one2014
Better long-term survival in young patients with non-metastatic colorectal cancer after surgery, an analysis of 69,835 patients in SEER database.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Hydroxyethyl starch 200/0.5 decreases circulating tumor cells of colorectal cancer patients and reduces metastatic potential of colon cancer cell line through inhibiting platelets activation.Medical oncology (Northwood, London, England) · 2015Trial
- A Retrospective Multicenter Study of the Clinicopathological Characteristics and Prognosis of Young Adult Patients with Colorectal Cancer: Effects of Chemotherapy on Prognosis.Journal of clinical medicine · 2023Article
- Development of an immune-related gene prognostic risk model and identification of an immune infiltration signature in the tumor microenvironment of colon cancer.BMC gastroenterology · 2023Article
- Risk factors and survival prediction of young breast cancer patients with liver metastases: a population-based study.Frontiers in endocrinology · 2023Article
- Estimating short-term and long-term survival in rectal cancer patients using cure model.Journal of family medicine and primary care · 2022Article
- Retrospective Cohort Analysis of the Effect of Age on Lymph Node Harvest, Positivity, and Ratio in Colorectal Cancer.Cancers · 2022Article
- Prognostic value of the NLR combined with CIP2A in the serum of patients with colorectal cancer.BMC surgery · 2021Article
- Updates on Clinical Use of Liquid Biopsy in Colorectal Cancer Screening, Diagnosis, Follow-Up, and Treatment Guidance.Frontiers in cell and developmental biology · 2021Review
- Worse treatment response to neoadjuvant chemoradiotherapy in young patients with locally advanced rectal cancer.BMC cancer · 2020Article
- Prognosis factors of advanced gastric cancer according to sex and age.World journal of clinical cases · 2020Article
- Analysis of factors potentially predicting prognosis of colorectal cancer.World journal of gastrointestinal oncology · 2019Article
- Familial and non-familial risk factors associated with colorectal cancer survival in young and middle-aged patients.International journal of colorectal disease · 2019Article
- Early-onset colorectal cancer in young individuals.Molecular oncology · 2019Review
- Colon Cancer in Young Adults: Trends and Their Implications.Current oncology reports · 2019Review
- Prognosis Prediction of Colorectal Cancer Using Gene Expression Profiles.Frontiers in oncology · 2019Article
- Surveillance, Epidemiology, and End Results (SEER) and SEER-Medicare Databases: Use in Clinical Research for Improving Colorectal Cancer Outcomes.Clinics in colon and rectal surgery · 2019Review
- Real-world study of a novel prognostic scoring system: for a more precise prognostication and better clinical treatment guidance in stages II and III colon cancer.International journal of colorectal disease · 2018Article
- Poorer prognosis in young female patients with non-metastatic colorectal cancer: a hospital-based analysis of 5,047 patients in China.Cancer management and research · 2018Article
- Age-specific impact on the survival of gastric cancer patients with distant metastasis: an analysis of SEER database.Oncotarget · 2017Article
- Adjuvant chemotherapy for patients with ypT0-2N0-category after neoadjuvant chemoradiotherapy for rectal cancer.Molecular and clinical oncology · 2017Article
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Authors and funding
6 authors.
Funding
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Abstract
objectiveTo compare the long-term survival of colorectal cancer (CRC) in young patients with elderly ones.
methodsUsing Surveillance, Epidemiology, and End Results (SEER) population-based data, we identified 69,835 patients with non-metastatic colorectal cancer diagnosed between January 1, 1988 and December 31, 2003 treated with surgery. Patients were divided into young (40 years and under) and elderly groups (over 40 years of age). Five-year cancer specific survival data were obtained. Kaplan-Meier methods were adopted and multivariable Cox regression models were built for the analysis of long-term survival outcomes and risk factors.
resultsYoung patients showed significantly higher pathological grading (p<0.001), more cases of mucinous and signet-ring histological type (p<0.001), later AJCC stage (p<0.001), more lymph nodes (≥ 12 nodes) dissected (p<0.001) and higher metastatic lymph node ratio (p<0.001). The 5-year colorectal cancer specific survival rates were 78.6% in young group and 75.3% in elderly group, which had significant difference in both univariate and multivariate analysis (P<0.001). Further analysis showed this significant difference only existed in stage II and III patients.
conclusionsCompared with elderly patients, young patients with colorectal cancer treated with surgery appear to have unique characteristics and a higher cancer specific survival rate although they presented with higher proportions of unfavorable biological behavior as well as advanced stage disease.
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