Evidence map›Paper›PMID 24699854›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2014

Soy-dairy protein blend and whey protein ingestion after resistance exercise increases amino acid transport and transporter expression in human skeletal muscle.

P T Reidy, D K Walker, J M Dickinson, D M Gundermann, M J Drummond, K L Timmerman, M B Cope, R Mukherjea, K Jennings, E Volpi and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

P T ReidyDivision of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas;
D K WalkerDivision of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas;
J M DickinsonDivision of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas;
D M GundermannDivision of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas;
M J DrummondDepartment of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas;
K L TimmermanDepartment of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas;
M B CopeDuPont Nutrition & Health, St. Louis, Missouri.
R MukherjeaDuPont Nutrition & Health, St. Louis, Missouri.
K JenningsDepartment of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas; and.
E VolpiDepartment of Internal Medicine/Geriatrics, University of Texas Medical Branch, Galveston, Texas; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas;
B B RasmussenDivision of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas; Department of Nutrition & Metabolism, University of Texas Medical Branch, Galveston, Texas; Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas; blrasmus@utmb.edu.
The University of Texas Medical Branch at Galveston · USDuPont (United States) · US

Funding

UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
UTMB Clinical and Translational Science AwardUL1TR000071 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRASIER, ALLAN R. · 2012 to 2014
$14.4M
Nutritional and Contractile Regulation of Muscle GrowthR01AR049877 · NIAMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI RASMUSSEN, BLAKE B · 2004 to 2012
$3.3M
Interdisciplinary Rehabilitation Research TrainingT32HD007539 · NICHD · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI OTTENBACHER, KENNETH J. · 2001 to 2011
$1.1M
NCATS NIH HHS UL1 TR000071NIAMS NIH HHS R01 AR-049877NIA NIH HHS P30 AG-024832NIA NIH HHS P30 AG024832NICHD NIH HHS T32-HD-07539
6 · The paper itself

Abstract

Increasing amino acid availability (via infusion or ingestion) at rest or postexercise enhances amino acid transport into human skeletal muscle. It is unknown whether alterations in amino acid availability, from ingesting different dietary proteins, can enhance amino acid transport rates and amino acid transporter (AAT) mRNA expression. We hypothesized that the prolonged hyperaminoacidemia from ingesting a blend of proteins with different digestion rates postexercise would enhance amino acid transport into muscle and AAT expression compared with the ingestion of a rapidly digested protein. In a double-blind, randomized clinical trial, we studied 16 young adults at rest and after acute resistance exercise coupled with postexercise (1 h) ingestion of either a (soy-dairy) protein blend or whey protein. Phenylalanine net balance and transport rate into skeletal muscle were measured using stable isotopic methods in combination with femoral arteriovenous blood sampling and muscle biopsies obtained at rest and 3 and 5 h postexercise. Phenylalanine transport into muscle and mRNA expression of select AATs [system L amino acid transporter 1/solute-linked carrier (SLC) 7A5, CD98/SLC3A2, system A amino acid transporter 2/SLC38A2, proton-assisted amino acid transporter 1/SLC36A1, cationic amino acid transporter 1/SLC7A1] increased to a similar extent in both groups (P < 0.05). However, the ingestion of the protein blend resulted in a prolonged and positive net phenylalanine balance during postexercise recovery compared with whey protein (P < 0.05). Postexercise myofibrillar protein synthesis increased similarly between groups. We conclude that, while both protein sources enhanced postexercise AAT expression, transport into muscle, and myofibrillar protein synthesis, postexercise ingestion of a protein blend results in a slightly prolonged net amino acid balance across the leg compared with whey protein.

Indexed as

Administration, OralAdultAmino AcidsAmino Acid Transport SystemsDietary ProteinsDouble-Blind MethodEatingFemaleHumansMaleMilk ProteinsMuscle, SkeletalResistance TrainingSoybean ProteinsUp-RegulationWhey ProteinsAmino AcidsAmino Acid Transport SystemsDietary ProteinsMilk ProteinsSoybean ProteinsWhey ProteinsleucinemTORC1muscle protein synthesisprotein anabolismprotein metabolism

Identifiers

PMID24699854
PMCPMC4044402
OpenAlexW2162315546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.