ArticleSleep & breathing = Schlaf & Atmung2014
Cardiopulmonary coupling analysis: changes before and after treatment with a mandibular advancement device.
Article in Sleep & breathing = Schlaf & Atmung, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
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Who cites it
13 citing papers in PubMed.
- Longitudinal changes in sleep quality in male patients with alcohol dependence receiving far-infrared ray therapy: associations with alterations in circulating pro-inflammatory cytokines.BMC psychiatry · 2025Trial
- Ambulatory screening tool for sleep apnea: analyzing a single-lead electrocardiogram signal (ECG).Sleep & breathing = Schlaf & Atmung · 2018Trial
- Evidence of a relationship between circulating ghrelin and sleep quality in male alcohol-dependent patients after abstinence.BMC psychiatry · 2025Article
- Cardiopulmonary coupling-calculated sleep stability and nocturnal heart rate kinetics as a potential indicator for cardiovascular health: a relationship with blood pressure dipping.Frontiers in sleep · 2024Article
- Review
- Automated Apnea-Hypopnea Index from Oximetry and Spectral Analysis of Cardiopulmonary Coupling.Annals of the American Thoracic Society · 2021Article
- Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology-Implications for Health and Disease.Frontiers in neuroscience · 2021Review
- Impact of Catheter Ablation on Sleep Quality and Relationship Between Sleep Stability and Recurrence of Paroxysmal Atrial Fibrillation After Successful Ablation: 24-Hour Holter-Based Cardiopulmonary Coupling Analysis.Journal of the American Heart Association · 2020Article
- Reinventing polysomnography in the age of precision medicine.Sleep medicine reviews · 2020Review
- Electrocardiogram-based sleep analysis for sleep apnea screening and diagnosis.Sleep & breathing = Schlaf & Atmung · 2020Article
- Sleep apnea detection: accuracy of using automated ECG analysis compared to manually scored polysomnography (apnea hypopnea index).Sleep & breathing = Schlaf & Atmung · 2019Article
- Article
- The effect of continuous positive airway pressure on cardiopulmonary coupling.Sleep & breathing = Schlaf & Atmung · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study is to evaluate the changes of sleep quality in patients using a mandibular advancement device (MAD) for obstructive sleep apnea (OSA) based upon cardiopulmonary coupling (CPC).
methodsA total of 52 patients (mean age 53.7±9.6 years, range 33-74 years) were included in this study. Of them, there were 47 males (90.4%). All subjects were diagnosed with OSA after in-laboratory full-night polysomnography and reevaluated after 3-month use of a MAD. At baseline, apnea-hypopnea index (AHI) was 33.6±17.0, Epworth sleepiness scale was 10.5±4.8, and Pittsburgh sleep quality index was 5.8±2.8. The CPC parameters were extracted from single-lead electrocardiography of polysomnography. We compared CPC parameters at baseline with those after 3-month use of a MAD.
resultsAll respiratory indices improved with the use of MAD. However, there were no differences in the sleep architectures except N3 sleep (3.7±4.3 to 6.9±6.4%, p<0.001). The CPC parameters showed a significant improvement with the use of MAD. Low-frequency coupling (59.5±16.1 to 47.7±14.8%, p<0.001) and elevated low-frequency coupling (44.6±18.4 to 32.6±15.7%, p<0.001) significantly decreased. High-frequency coupling (28.6±16.0 to 36.5±15.7%, p=0.004) and very low frequency coupling (11.7±7.2 to 15.3±6.6%, p=0.028) significantly increased. The change of AHI significantly correlated with changes of the CPC parameters: negatively correlated with high-frequency coupling change (r=-0.572, p<0.001) and positively correlated with low-frequency and elevated low-frequency coupling changes (r=0.604 and 0.497, respectively; p<0.001 in both). However, the changes of Epworth sleepiness scale and Pittsburgh sleep quality index after MAD therapy showed no significant correlation with the changes in the CPC parameters.
conclusionsTo our knowledge, this is the first study to evaluate the quality of sleep in patients using a MAD for their OSA based upon CPC analysis. Low-frequency coupling decreased as AHI improved, while high-frequency coupling increased as AHI improved. The CPC parameters showed that the sleep quality was improved by MAD therapy.
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Registered trials
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