ArticleNature communications2014
Wnt signalling underlies the evolution of new phenotypes and craniofacial variability in Lake Malawi cichlids.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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Who cites it
50 citing papers in PubMed, 103 citations in OpenAlex.
- Developmental divergence in gene regulation underlies trophic innovation in Lake Victoria cichlids.Proceedings. Biological sciences · 2026Article
- Neural crest gene regulatory networks as drivers of development, diversification and disease.Nature reviews. Molecular cell biology · 2026Review
- Ancestral splice variation is a key substrate for rapid diversification in African cichlids.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- From hatching to juvenile: Larval development of Vieja fenestrata (Teleostei: Cichlidae).Journal of fish biology · 2024Article
- Foraging-induced craniofacial plasticity is associated with an early, robust and dynamic transcriptional response.Proceedings. Biological sciences · 2024Article
- Developmental bias as a cause and consequence of adaptive radiation and divergence.Frontiers in cell and developmental biology · 2024Review
- Epigenetics and the evolution of form: Experimental manipulation of a chromatin modification causes species-specific changes to the craniofacial skeleton.Evolution & development · 2024Article
- Functional trait plasticity diverges between sexes in African cichlids: A contribution toward ecological sexual dimorphism?Ecology and evolution · 2023Article
- Rapid and biased evolution of canalization during adaptive divergence revealed by dominance in gene expression variability during Arctic charr early development.Communications biology · 2023Article
- Neural crest cells as a source of microevolutionary variation.Seminars in cell & developmental biology · 2023Review
- The transcriptional state and chromatin landscape of cichlid jaw shape variation across species and environments.Molecular ecology · 2023Article
- Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- East African cichlid fishes.EvoDevo · 2023Review
- Covariation of brain and skull shapes as a model to understand the role of crosstalk in development and evolution.Evolution & development · 2023Article
- Article
- Review
- Wnt/β-catenin Signaling Controls Maxillofacial Hyperostosis.Journal of dental research · 2022Article
- Early shape divergence of developmental trajectories in the jaw of galeomorph sharks.Frontiers in zoology · 2022Article
- The Evolution of Feeding Mechanics in the Danioninae, or Why Giant Danios Don't Suck Like Zebrafish.Integrative organismal biology (Oxford, England) · 2022Article
- The cichlid oral and pharyngeal jaws are evolutionarily and genetically coupled.Nature communications · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Progress towards understanding adaptive radiations at the mechanistic level is still limited with regard to the proximate molecular factors that both promote and constrain evolution. Here we focus on the craniofacial skeleton and show that expanded Wnt/β-catenin signalling early in ontogeny is associated with the evolution of phenotypic novelty and ecological opportunity in Lake Malawi cichlids. We demonstrate that the mode of action of this molecular change is to effectively lock into place an early larval phenotype, likely through accelerated rates of bone deposition. However, we demonstrate further that this change toward phenotypic novelty may in turn constrain evolutionary potential through the corresponding reduction in craniofacial plasticity at later stages of ontogeny. In all, our data implicate the Wnt pathway as an important mediator of craniofacial form and offer new insights into how developmental systems can evolve to both promote and constrain evolutionary change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.