ArticleActa crystallographica. Section F, Structural biology communications2014
Crystallization and preliminary crystallographic analysis of manganese lipoxygenase.
Article in Acta crystallographica. Section F, Structural biology communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 6 citations in OpenAlex.
- Crystal structure of linoleate 13R-manganese lipoxygenase in complex with an adhesion protein.Journal of lipid research · 2016Article
- Manganese lipoxygenase of F. oxysporum and the structural basis for biosynthesis of distinct 11-hydroperoxy stereoisomers.Journal of lipid research · 2015Article
- Connecting lipoxygenase function to structure by electron paramagnetic resonance.Accounts of chemical research · 2014Article
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3 authors at 1 institution in 1 country.
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Abstract
Lipoxygenases constitute a family of nonhaem metal enzymes with catalytic iron or, occasionally, catalytic manganese. Lipoxygenases oxidize polyunsaturated fatty acids with position specificity and stereospecificity to hydroperoxides, which contribute to inflammation and the development of cancer. Little is known about the structural differences between lipoxygenases with Fe or Mn and the metal-selection mechanism. A Pichia pastoris expression system was used for the production of the manganese lipoxygenase of the take-all fungus of wheat, Gaeumannomyces graminis. The active enzyme was treated with α-mannosidase, purified to apparent homogeneity and subjected to crystal screening and X-ray diffraction. The crystals diffracted to 2.6 Å resolution and belonged to space group C2, with unit-cell parameters a = 226.6, b = 50.6, c = 177.92 Å, β = 91.70°.
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