Evidence map›Paper›PMID 24699730›Full record

ArticleActa crystallographica. Section F, Structural biology communications2014

1.55 Å resolution X-ray crystal structure of Rv3902c from Mycobacterium tuberculosis.

Bharat G Reddy, Derek B Moates, Heung-Bok Kim, Todd J Green, Chang-Yub Kim, Thomas C Terwilliger, Lawrence J DeLucas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bharat G ReddyDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35233, USA.
Derek B MoatesDepartment of Biology, University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35233, USA.
Heung-Bok KimBioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Todd J GreenDepartment of Microbiology, University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35233, USA.
Chang-Yub KimBioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Thomas C TerwilligerBioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Lawrence J DeLucasDepartment of Optometry, University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35233, USA.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
STRUCTURAL ORGANIZATION AND PROTEOMICS OF TBP50GM062410 · NIGMS · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI TERWILLIGER, THOMAS C. · 2000 to 2005
$34.7M
NCI NIH HHS 5P30CA13148-37NCI NIH HHS P30 CA013148NIGMS NIH HHS P50 GM062410NIGMS NIH HHS P50 GM62410
6 · The paper itself

Abstract

The crystallographic structure of the Mycobacterium tuberculosis (TB) protein Rv3902c (176 residues; molecular mass of 19.8 kDa) was determined at 1.55 Å resolution. The function of Rv3902c is unknown, although several TB genes involved in bacterial pathogenesis are expressed from the operon containing the Rv3902c gene. The unique structural fold of Rv3902c contains two domains, each consisting of antiparallel β-sheets and α-helices, creating a hand-like binding motif with a small binding pocket in the palm. Structural homology searches reveal that Rv3902c has an overall structure similar to that of the Salmonella virulence-factor chaperone InvB, with an r.m.s.d. for main-chain atoms of 2.3 Å along an aligned domain.

Indexed as

Protein ConformationProtein FoldingBacterial ProteinsCrystallizationCrystallography, X-RayModels, MolecularMycobacterium tuberculosisBacterial ProteinsMycobacterium tuberculosisnovel foldRv3902cvirulence-factor chaperone

Identifiers

PMID24699730
PMCPMC3976054

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.