ArticlePLoS genetics2014
Sox5 functions as a fate switch in medaka pigment cell development.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 69 citations in OpenAlex.
- A Simple Method for RNA-Seq of Manually Isolated Chromatophores in Oryzias Fishes.Development, growth & differentiation · 2026Article
- Tyrosinase-Deficient Skin Melanophore Lineage inInternational journal of molecular sciences · 2026Article
- Specialized molecular pathways drive the formation of light-scattering assemblies in leucophores.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pax7 is involved in leucophore formation in goldfish and gene knockout improves the transparency of transparent goldfish.Fish physiology and biochemistry · 2024Article
- A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish.Development (Cambridge, England) · 2023Article
- Zebrafish pigment cells develop directly from persistent highly multipotent progenitors.Nature communications · 2023Article
- Heme-Peroxidase 2 Modulated by POU2F1 and SOX5 is Involved in Pigmentation in Pacific Oyster (Crassostrea gigas).Marine biotechnology (New York, N.Y.) · 2022Article
- Analysis of yellow mutant rainbow trout transcriptomes at different developmental stages reveals dynamic regulation of skin pigmentation genes.Scientific reports · 2022Article
- Cell Fate Decisions in the Neural Crest, from Pigment Cell to Neural Development.International journal of molecular sciences · 2021Review
- Evolution of pigment cells and patterns: recent insights from teleost fishes.Current opinion in genetics & development · 2021Review
- Review
- Brazilian silverside,PeerJ · 2021Article
- Identification and Characterization of Highly Fluorescent Pigment Cells in Embryos of the Arabian Killifish (iScience · 2020Article
- Identification ofG3 (Bethesda, Md.) · 2020Article
- Developmental and Cellular Basis of Vertical Bar Color Patterns in the East African Cichlid FishFrontiers in cell and developmental biology · 2020Article
- Fate plasticity and reprogramming in genetically distinct populations ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Developmental and comparative transcriptomic identification of iridophore contribution to white barring in clownfish.Pigment cell & melanoma research · 2019Article
- A systems biology approach uncovers the core gene regulatory network governing iridophore fate choice from the neural crest.PLoS genetics · 2018Article
- Distinct interactions of Sox5 and Sox10 in fate specification of pigment cells in medaka and zebrafish.PLoS genetics · 2018Article
- Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements.BMC biology · 2018Article
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanisms generating diverse cell types from multipotent progenitors are crucial for normal development. Neural crest cells (NCCs) are multipotent stem cells that give rise to numerous cell-types, including pigment cells. Medaka has four types of NCC-derived pigment cells (xanthophores, leucophores, melanophores and iridophores), making medaka pigment cell development an excellent model for studying the mechanisms controlling specification of distinct cell types from a multipotent progenitor. Medaka many leucophores-3 (ml-3) mutant embryos exhibit a unique phenotype characterized by excessive formation of leucophores and absence of xanthophores. We show that ml-3 encodes sox5, which is expressed in premigratory NCCs and differentiating xanthophores. Cell transplantation studies reveal a cell-autonomous role of sox5 in the xanthophore lineage. pax7a is expressed in NCCs and required for both xanthophore and leucophore lineages; we demonstrate that Sox5 functions downstream of Pax7a. We propose a model in which multipotent NCCs first give rise to pax7a-positive partially fate-restricted intermediate progenitors for xanthophores and leucophores; some of these progenitors then express sox5, and as a result of Sox5 action develop into xanthophores. Our results provide the first demonstration that Sox5 can function as a molecular switch driving specification of a specific cell-fate (xanthophore) from a partially-restricted, but still multipotent, progenitor (the shared xanthophore-leucophore progenitor).
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