SynthesisPLoS genetics2014
A central role for GRB10 in regulation of islet function in man.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 8 pooled it
13.1field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
112 citing papers in PubMed, 8 syntheses or guidelines pooled it, 199 citations in OpenAlex.
- Associations Between TCF7L2, PPARγ, and KCNJ11 Genotypes and Insulin Response to an Oral Glucose Tolerance Test: A Systematic Review.Molecular nutrition & food research · 2025Pooled it
- Genetic Studies of Gestational Diabetes and Glucose Metabolism in Pregnancy.Current diabetes reports · 2020Pooled it
- Pooled it
- Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.Nature genetics · 2019Pooled it
- Assessing the causal association of glycine with risk of cardio-metabolic diseases.Nature communications · 2019Pooled it
- Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.Nature communications · 2018Pooled it
- Pooled it
- Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.The Journal of clinical investigation · 2015Pooled it
- Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases.Nature reviews. Endocrinology · 2026Review
- Genome-Wide Discovery Reveals Adipose-Specific and Systemic Regulators of Insulin Resistance.medRxiv : the preprint server for health sciences · 2026Article
- Targeting the PI3K Pathway: Advancements and Achievements in Breast Cancer Therapy.Current pharmaceutical design · 2025Review
- Genetic Underpinnings of Fasting and Oral Glucose-stimulated Based Insulin Sensitivity Indices.The Journal of clinical endocrinology and metabolism · 2024Article
- Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology.Nature metabolism · 2024Article
- Article
- [A ssociations of short-term ambient particulate matter exposure andBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Article
- Associations of diabetes, circulating protein biomarkers, and risk of pancreatic cancer.British journal of cancer · 2024Article
- Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.Nature genetics · 2024Article
- Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations.Genome medicine · 2024Article
- TheFrontiers in endocrinology · 2024Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
64 authors at 20 institutions in 9 countries.
Inga ProkopenkoOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, United Kingdom.
Wenny PoonDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Reedik MägiWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Estonian Genome Center, University of Tartu, Tartu, Estonia.
Rashmi Prasad BDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
S Albert SalehiDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Peter AlmgrenDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Peter OsmarkDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Nabila Bouatia-NajiUniversity of Lille Nord de France, Lille, France; CNRS UMR8199, Institut Pasteur de Lille, Lille, France; INSERM U970, Paris Cardiovascular Research Center PARCC, Paris, France.
Nils WierupDepartment of Clinical Science, Neuroendocrine Cell Biology, Lund University Diabetes Centre, Malmö, Sweden.
Tove FallDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Alena StančákováDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Adam BarkerMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Vasiliki LagouOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Clive OsmondMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.
Weijia XiePeninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom.
Jari LahtiInstitute of Behavioural Sciences, University of Helsinki, Helsinki, Finland; Folkhälsan Research Centre, Helsinki, Finland.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Yu-Ching ChengDivision of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Jie LiuDivision of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Jeffrey R O'ConnellDivision of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Paul A BlomstedtDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland; Department of Mathematics, Åbo Akademi University, Turku, Finland.
Joao FadistaDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Sami AlkayyaliDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Tasnim DayehEpigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University, CRC, Scania University Hospital, Malmö, Sweden.
Emma AhlqvistDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Jalal TaneeraDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Cecile LecoeurUniversity of Lille Nord de France, Lille, France; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.
Ashish KumarWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland.
Ola HanssonDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Karin HanssonDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
Benjamin F VoightDepartment of Pharmacology and Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Hyun Min KangDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.
Claire Levy-MarchalINSERM - Institut de Santé Publique, Paris, France; INSERM CIC EC 05, Hôpital Robert Debré, Paris, France.
Vincent VatinUniversity of Lille Nord de France, Lille, France; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.
Aarno PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; Program in Medical and Population Genetics and Genetics Analysis Platform, The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusettes, United States of America.
Ann-Christine SyvänenMolecular Medicine, Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Andrea MariCNR Institute of Biomedical Engineering, Padova, Italy.
Michael N WeedonPeninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom.
Ruth J F LoosMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Ken K OngMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Peter NilssonDepartment of Clinical Science, Internal Medicine, Skåne University Hospital Malmö, Malmö, Sweden.
Bo IsomaaFolkhälsan Research Centre, Helsinki, Finland; Department of Social Service and Health Care, Jakobstad, Finland.
Tiinamaija TuomiFolkhälsan Research Centre, Helsinki, Finland; Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Michael StumvollUniversity of Leipzig, Department of Medicine, Leipzig, Germany; University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany.
Elisabeth WidenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Timo A LakkaInstitute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Anke TönjesUniversity of Leipzig, Department of Medicine, Leipzig, Germany; University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Johanna KuusistoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Timothy M FraylingPeninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom.
Philippe FroguelDepartment of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, United Kingdom; University of Lille Nord de France, Lille, France; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.
Mark WalkerInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Johan G ErikssonFolkhälsan Research Centre, Helsinki, Finland; Helsinki University, Department of General Practice and Primary Health Care, Helsinki, Finland; Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.
Charlotte LingEpigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University, CRC, Scania University Hospital, Malmö, Sweden.
Peter KovacsUniversity of Leipzig, Department of Medicine, Leipzig, Germany; University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany.
Erik IngelssonWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Mark I McCarthyOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kindom.
Alan R ShuldinerDivision of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Baltimore Geriatric Research, Education and Clinical Center, Baltimore, Maryland, United States of America.
Kristi D SilverDivision of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Baltimore Geriatric Research, Education and Clinical Center, Baltimore, Maryland, United States of America.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Leif GroopDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Valeriya LyssenkoDepartment of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden; Steno Diabetes Center A/S, Gentofte, Denmark.
Lund University · SECentre for Human Genetics · GBUniversity of Cambridge · GBUniversity of Eastern Finland · FIUniversity of Maryland, Baltimore · USCentre National de la Recherche Scientifique · FRUniversity of Helsinki · FIIFB Adiposity Diseases · DEUniversity of Exeter · GBUppsala University · SEScania (Sweden) · SEUniversity of Michigan · USÅbo Akademi University · FIBroad Institute · USFolkhälsans Forskningscentrum · FIHelsinki University Hospital · FIInserm · FRMRC Lifecourse Epidemiology Unit · GBNewcastle University · GBSkåne University Hospital · SE
Funding
Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI ONUKWUGHA, EBERECHUKWU · 2002 to 2009
$20.2MZINC THERAPY FOR SCLERODERMA--PHASE I STUDYM01RR002719 · NCRR · JOHNS HOPKINS UNIVERSITY · PI SEO, PHILIP · 1986 to 2007
$20.2MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3MJHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI AHIMA, REXFORD S. · 2013 to 2017
$9.7MDiabetes Research and Training CenterP60DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WONDISFORD, FREDRIC E. · 2008 to 2012
$9.1MGENETICS OF DIABETES IN THE AMISHR01DK054261 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2000 to 2009
$5.1MLinkage of 15q to Insulin Levels in the Old Order AmishR01DK068495 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI SILVER, KRISTI · 2004 to 2007
$1.2MGenome-wide Association in Families: Data Integrity, Design and Methods IssueU01HL084756 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI O'CONNELL, JEFFREY R · 2006 to 2008
$880kMedical Research Council G0601261Medical Research Council G1002084Medical Research Council MC_U106179471Medical Research Council MC_U106179472Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2NCRR NIH HHS M01 RR002719NCRR NIH HHS M01 RR016500NCRR NIH HHS M01 RR02719NCRR NIH HHS M01 RR16500NHLBI NIH HHS U01 HL084756NHLBI NIH HHS U01 HL84756NIDDK NIH HHS P30 DK072488NIDDK NIH HHS P60 DK079637NIDDK NIH HHS P60 DK79637NIDDK NIH HHS R01 DK054261NIDDK NIH HHS R01 DK068495NIDDK NIH HHS R01 DK54261NIDDK NIH HHS R01 DK68495Wellcome TrustWellcome Trust 083270Wellcome Trust 089062Wellcome Trust 089062/Z/09/ZWellcome Trust 090367Wellcome Trust 090532Wellcome Trust 098381Wellcome Trust 89061/Z/09/Z
Abstract
Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion in different tissues. GRB10 knock-down in human pancreatic islets showed reduced insulin and glucagon secretion, which together with changes in insulin sensitivity may explain the paradoxical reduction of glucose despite a decrease in insulin secretion. Together, these findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism and contribute to T2D pathogenesis. The data also emphasize the need in genetic studies to consider whether risk alleles are inherited from the mother or the father.
Indexed as
AllelesDiabetes Mellitus, Type 2FastingGenome-Wide Association StudyGlucoseGRB10 Adaptor ProteinHumansInsulinInsulin ResistanceIslets of LangerhansMaleMiddle AgedPolymorphism, Single NucleotideReceptor, InsulinSignal TransductionGlucoseGRB10 Adaptor ProteinGRB10 protein, humanInsulinReceptor, Insulin
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