Evidence map›Paper›PMID 24699357›Full record

ReviewFrontiers in neuroendocrinology2014

Vital and vulnerable functions of the primate placenta critical for infant health and brain development.

Christopher L Coe, Gabriele R Lubach

Open access · greenAbstract readReview
In one paragraph

Review in Frontiers in neuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
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  8. Article
  9. Developmental changes in the endocrine stress response in orangutans (Pongo pygmaeus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019
    Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher L CoeHarlow Center for Biology Psychology, University of Wisconsin-Madison, United States. Electronic address: ccoe@wisc.edu.
Gabriele R LubachHarlow Center for Biology Psychology, University of Wisconsin-Madison, United States.
University of Wisconsin–Madison · US

Funding

ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI KAUFMAN, PAUL L · 1985 to 2011
$106.7M
STATISTICAL COREP01HD039386 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COE, CHRISTOPHER · 2001 to 2011
$14.0M
Maternal Flu Infection and Brain Development in PrimatesR01AI067518 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI COE, CHRISTOPHER L · 2006 to 2010
$2.3M
PRENATAL STRESS AND IMMUNE RESPONSIVENESSR01AI046521 · NIAID · UNIVERSITY OF WISCONSIN MADISON · PI COE, CHRISTOPHER L. · 2000 to 2004
$1.8M
Gestational Stress and Impaired Iron Homeostasis in the Young InfantR01HD057064 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI COE, CHRISTOPHER L · 2009 to 2013
$1.6M
NCRR NIH HHS P51 RR000167NCRR NIH HHS P51RR000167NIAID NIH HHS AI067518NIAID NIH HHS R01 AI046521NIAID NIH HHS R01 AI067518NICHD NIH HHS HD057064NICHD NIH HHS HD39386NICHD NIH HHS P01 HD039386NICHD NIH HHS R01 HD057064
6 · The paper itself

Abstract

The placenta is essential to mammalian pregnancy with many roles beyond just nutrient supply, including both endocrine and immune functions. During the course of evolution, the placenta of higher primates has acquired some unique features, including the capacity to secrete corticotropin-releasing hormone (CRH). In addition, a placental receptor for IgG enables particularly high levels of protective maternal antibody to reach the fetus before birth. This paper reviews the placental biology of primates, and discusses its involvement in adrenocortical hormone activity during pregnancy, the transfer of maternal antibody, and finally the delivery of maternal iron to the fetus, which is needed for normal brain development. An understanding of these vital functions during a full-term, healthy pregnancy provides insights into the consequences of gestational disturbances, such as maternal stress, illness, and undernutrition, which have even larger ramifications if the infant is born premature.

Indexed as

AnimalsBrainCorticotropin-Releasing HormoneFemaleFetusHumansPituitary-Adrenal SystemPlacentaPregnancyPrimatesCorticotropin-Releasing HormoneAnemiaAntibodyCortisolImmune, IronMonkeyPlacentaPregnancyPrematurityPrimateStress

Identifiers

PMID24699357
PMCPMC4175171
OpenAlexW2005178126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.