Evidence map›Paper›PMID 24698962›Full record

ArticleThe American journal of surgical pathology2014

VCL-ALK renal cell carcinoma in children with sickle-cell trait: the eighth sickle-cell nephropathy?

Nathaniel E Smith, Andrea T Deyrup, Adrian Mariño-Enriquez, Jonathan A Fletcher, Julia A Bridge, Peter B Illei, George J Netto, Pedram Argani

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of surgical pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
    Guideline
  3. Guideline
  4. Review
  5. Molecularly defined renal cell carcinomas.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026
    Review
  6. ALK-Rearranged renal neoplasms: update on an institutional cohort.Virchows Archiv : an international journal of pathology · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. ALK-rearranged renal cell carcinoma with TPM3::ALK gene fusion and review of the literature.Virchows Archiv : an international journal of pathology · 2023
    Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nathaniel E SmithDepartments of *Pathology ∥Urology ¶Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD †Department of Pathology, University of South Carolina School of Medicine-Greenville, Greenville, SC ‡Department of Pathology, Brigham and Women's Hospital, Boston, MA §Departments of Pathology/Microbiology, Pediatrics and Orthopedic Surgery, University of Nebraska Medical Center, Omaha, NE.
Andrea T Deyrup
Adrian Mariño-Enriquez
Jonathan A Fletcher
Julia A Bridge
Peter B Illei
George J Netto
Pedram Argani
Johns Hopkins University · USBrigham and Women's Hospital · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

We report the third case of a renal cell carcinoma bearing a fusion of the vinculin (VCL) and anaplastic lymphoma kinase (ALK) genes. Like the 2 other reported cases, this neoplasm occurred in a young patient (6 y old) with sickle-cell trait and demonstrated distinctive morphologic features including medullary epicenter, discohesive polygonal or spindle-shaped cells with prominent cytoplasmic vacuoles, and prominent lymphocytic infiltrate. The neoplastic cells demonstrated focal membranous labeling for ALK protein by immunohistochemistry, ALK gene rearrangement by fluorescence in situ hybridization, and a specific VCL-ALK gene fusion by reverse transcriptase polymerase chain reaction. VCL-ALK renal cell carcinoma may represent the eighth sickle-cell nephropathy.

Indexed as

Gene FusionAnaplastic Lymphoma KinaseBiomarkers, TumorCarcinoma, Renal CellChildGene RearrangementGenetic Predisposition to DiseaseHumansImmunohistochemistryIn Situ Hybridization, FluorescenceKidney NeoplasmsMaleNephrectomyPhenotypeReceptor Protein-Tyrosine KinasesReverse Transcriptase Polymerase Chain ReactionALK protein, humanAnaplastic Lymphoma KinaseBiomarkers, TumorReceptor Protein-Tyrosine KinasesVCL protein, humanVinculin

Identifiers

PMID24698962
PMCPMC4352307
OpenAlexW2088011744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.