ArticlePLoS genetics2014
Synergistic interactions between the molecular and neuronal circadian networks drive robust behavioral circadian rhythms in Drosophila melanogaster.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 19 citations in OpenAlex.
- miR-2940-1 is involved in the circadian regulation of oviposition in Aedes albopictus.Insect science · 2025Article
- Organismal landscape of clock cells and circadian gene expression inbioRxiv : the preprint server for biology · 2023Article
- The circadian clock gatesProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila.BMC genomics · 2019Article
- On Variations in the Level of PER in Glial Clocks ofFrontiers in physiology · 2018Article
- CLOCK stabilizes CYCLE to initiate clock function inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila.Nature communications · 2017Article
- Translation of CircRNAs.Molecular cell · 2017Article
- PDF Signaling Is an Integral Part of the Drosophila Circadian Molecular Oscillator.Cell reports · 2016Article
- The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing.The EMBO journal · 2015Article
- Clk post-transcriptional control denoises circadian transcription both temporally and spatially.Nature communications · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Most organisms use 24-hr circadian clocks to keep temporal order and anticipate daily environmental changes. In Drosophila melanogaster CLOCK (CLK) and CYCLE (CYC) initiates the circadian system by promoting rhythmic transcription of hundreds of genes. However, it is still not clear whether high amplitude transcriptional oscillations are essential for circadian timekeeping. In order to address this issue, we generated flies in which the amplitude of CLK-driven transcription can be reduced partially (approx. 60%) or strongly (90%) without affecting the average levels of CLK-target genes. The impaired transcriptional oscillations lead to low amplitude protein oscillations that were not sufficient to drive outputs of peripheral oscillators. However, circadian rhythms in locomotor activity were resistant to partial reduction in transcriptional and protein oscillations. We found that the resilience of the brain oscillator is depending on the neuronal communication among circadian neurons in the brain. Indeed, the capacity of the brain oscillator to overcome low amplitude transcriptional oscillations depends on the action of the neuropeptide PDF and on the pdf-expressing cells having equal or higher amplitude of molecular rhythms than the rest of the circadian neuronal groups in the fly brain. Therefore, our work reveals the importance of high amplitude transcriptional oscillations for cell-autonomous circadian timekeeping. Moreover, we demonstrate that the circadian neuronal network is an essential buffering system that protects against changes in circadian transcription in the brain.
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