ReviewThe Journal of hand surgery, European volume2015
Safety and tolerability of collagenase Clostridium histolyticum and fasciectomy for Dupuytren's contracture.
Review in The Journal of hand surgery, European volume, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Collagenase-mediated extracellular matrix targeting for enhanced drug penetration and therapeutic efficacy in nanoscale delivery systems for cancer therapy.Journal of nanobiotechnology · 2025Pooled it
- Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review.British medical bulletin · 2016Pooled it
- Anti-Tumour Necrosis Factor Therapy for Dupuytren's Disease: A Randomised Dose Response Proof of Concept Phase 2a Clinical Trial.EBioMedicine · 2018Trial
- The Impact of Emerging Therapies and Declining Physician Reimbursement on Dupuytren Disease Treatment: A 21 Year Review.Journal of hand surgery global online · 2026Article
- Flexor Tendon Rupture Following CollagenaseJournal of personalized medicine · 2026Review
- Collagenase Versus Operative Management for Dupuytren Contracture: A Propensity-matched Cohort of 16,888 Patients.Plastic and reconstructive surgery. Global open · 2026Article
- Treatment of Dupuytren Contracture Recurrence After Surgery With Collagenase Clostridium Histolyticum: A Retrospective Multicenter Series.Journal of hand surgery global online · 2026Article
- Evaluation of drug delivery vehicles for improved transduction of oncolytic adenoviruses in solid tumor tissue.Upsala journal of medical sciences · 2025Article
- Sex Difference in the Treatment of Dupuytren's Disease: A Systematic Review and Meta-Analysis of Clinical Trials.Plastic surgery (Oakville, Ont.) · 2024Article
- Challenges and innovations in the surgical treatment of advanced Dupuytren disease by percutaneous needle fasciotomy: indications, limitations, and medico-legal implications.Journal of orthopaedic surgery and research · 2024Article
- Application of Near Infrared Spectroscopy to Enhance Safety and Individualize Distraction of Severely Contracted Joints in Far-Advanced Dupuytren's Disease.Journal of clinical medicine · 2024Article
- Delayed vascular complication after collagenase injection for Dupuytren disease.BMC musculoskeletal disorders · 2023Article
- Dupuytren Cords Do Not Undergo Significant Histopathological Change After Collagenase Clostridium Histolyticum Injection.Hand (New York, N.Y.) · 2023Article
- Analysis of a National Database Investigating Development of Trigger Finger after Treatment of Dupuytren Disease.Plastic and reconstructive surgery. Global open · 2023Article
- Short-term efficacy and adverse effects of collagenase clostridium histolyticum injections, percutaneous needle fasciotomy and limited fasciectomy in the treatment of Dupuytren's contracture: a network meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2022Article
- Effect of Oral Prednisolone after Collagenase Injection for Dupuytren's Contracture: A Randomized, Controlled Trial with a 1-Year Follow-Up.Journal of hand and microsurgery · 2022Article
- Article
- Treatment Options for Dupuytren's Disease: Tips and Tricks.Plastic and reconstructive surgery. Global open · 2022Review
- Dupuytren's disease: using needles more across the world.The Journal of hand surgery, European volume · 2022Article
- Cost-Effectiveness and Patient Outcomes of Injectable Collagenase to Treat Dupuytren's Contracture.Cureus · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Safety was evaluated for collagenase Clostridium histolyticum (CCH) based on 11 clinical trials (N = 1082) and compared with fasciectomy data in a structured literature review of 48 European studies (N = 7727) for treatment of Dupuytren's contracture. Incidence of adverse events was numerically lower with CCH vs. equivalent complications from fasciectomy (median [range] incidence), including nerve injury (0% vs. 3.8% [0%-50+%]), neurapraxia (4.4% vs. 9.4% [0%-51.3%]), complex regional pain syndrome (0.1% vs. 4.5% [1.3%-18.5%]) and arterial injury (0% vs. 5.5% [0.8%-16.5%]). Tendon injury (0.3% vs. 0.1% [0%-0.2%]), skin injury (16.2% vs. 2.8% [0%-25.9%]) and haematoma (77.7% vs. 2.0% [0%-25%]) occurred at a numerically higher incidence with CCH than surgery. Adverse events in CCH trials not reported after fasciectomy included peripheral oedema; extremity pain; injection site pain, haemorrhage and swelling; tenderness; pruritus and lymphadenopathy. CCH-related adverse events were reported as predominantly injection-related and transient. These results may support clinical decision-making for treatment of Dupuytren's contracture.
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