ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2014
Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
130 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Behavioral and Psychological Symptoms that Predict Cognitive Decline or Impairment in Cognitively Normal Middle-Aged or Older Adults: a Meta-Analysis.Neuropsychology review · 2020Pooled it
- Subjective Cognitive Impairment and Affective Symptoms: A Systematic Review.The Gerontologist · 2016Pooled it
- From Subjective Cognitive Complaints to Dementia: Who is at Risk?: A Systematic Review.American journal of Alzheimer's disease and other dementias · 2016Pooled it
- Association of Subjective Cognitive Decline with Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Longitudinal Studies.The journal of prevention of Alzheimer's diseasePooled it
- Changes in MoCA scores with sequential administration of Trikatu Cūrṇa and Brahmi Ghṛta in mild cognitive impairment: an exploratory single-arm clinical study.Frontiers in medicine · 2026Trial
- Positive affect disrupts neurodegeneration effects on cognitive training plasticity in older adults.Social cognitive and affective neuroscience · 2024Trial
- Effects of combined training on neuropsychiatric symptoms and quality of life in patients with cognitive decline.Aging clinical and experimental research · 2021Trial
- Effects of Meditation and Music-Listening on Blood Biomarkers of Cellular Aging and Alzheimer's Disease in Adults with Subjective Cognitive Decline: An Exploratory Randomized Clinical Trial.Journal of Alzheimer's disease : JAD · 2018Trial
- Meditation and Music Improve Memory and Cognitive Function in Adults with Subjective Cognitive Decline: A Pilot Randomized Controlled Trial.Journal of Alzheimer's disease : JAD · 2017Trial
- Effects of Meditation versus Music Listening on Perceived Stress, Mood, Sleep, and Quality of Life in Adults with Early Memory Loss: A Pilot Randomized Controlled Trial.Journal of Alzheimer's disease : JAD · 2016Trial
- Dose-Response Relationship Between Sleep Regularity Index and Stage-Specific Alzheimer's Disease: Cross-Sectional Evidence from Japanese Adults.Geriatrics (Basel, Switzerland) · 2026Article
- Factors associated with subjective cognitive complaints in former American football players.Journal of the International Neuropsychological Society : JINS · 2026Article
- Associations between depressive symptoms and subjective cognitive decline among diverse Hispanics/Latinos: Results from the study of Latinos-investigation of Neurocognitive Aging (SOL-INCA).International psychogeriatrics · 2026Article
- Associations between subjective cognitive concern, brain network connectivity, and cognitive performance in cognitively normal older adults.Aging brain · 2026Article
- Clinical definition, biological characterization, and detection guidelines of subjective cognitive decline due to Alzheimer's disease and related dementia: A position paper from ISTAART SCD PIA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Relationship Between Subjective Cognitive Decline and Objective Cognitive Performance in Older Adults With Treatment-Resistant Late-Life Depression: The Role of Depression Severity.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Article
- Neuropsychiatric symptom phenotypes for early detection of risk in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Anxious-depressive symptoms and sleep disturbances across the Alzheimer disease spectrum.Nature. Mental health · 2025Article
- Body mass index changes and trajectories from midlife to late-life: association with subjective cognitive complaints in a 30-year Women's cohort study.Age and ageing · 2025Article
- Characterization of subclinical depressive and anxiety symptoms in older adults with subjective cognitive decline progressing to objective cognitive impairment: A prospective 4-year follow-up study.Journal of Alzheimer's disease : JAD · 2025Article
70 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveTo examine neuropsychiatric and neuropsychological predictors of progression from normal to early clinical stages of Alzheimer disease (AD).
methodsFrom a total sample of 559 older adults from the Massachusetts Alzheimer's Disease Research Center longitudinal cohort, 454 were included in the primary analysis: 283 with clinically normal cognition (CN), 115 with mild cognitive impairment (MCI), and 56 with subjective cognitive concerns (SCC) but no objective impairment, a proposed transitional group between CN and MCI. Two latent cognitive factors (memory-semantic, attention-executive) and two neuropsychiatric factors (affective, psychotic) were derived from the Alzheimer's Disease Centers' Uniform Data Set neuropsychological battery and Neuropsychiatric Inventory brief questionnaire. Factors were analyzed as predictors of time to progression to a worse diagnosis using a Cox proportional hazards regression model with backward elimination. Covariates included baseline diagnosis, gender, age, education, prior depression, antidepressant medication, symptom duration, and interaction terms.
resultsHigher/better memory-semantic factor score predicted lower hazard of progression (hazard ratio [HR] = 0.4 for 1 standard deviation [SD] increase, p <0.0001), and higher/worse affective factor score predicted higher hazard (HR = 1.3 for one SD increase, p = 0.01). No other predictors were significant in adjusted analyses. Using diagnosis as a sole predictor of transition to MCI, the SCC diagnosis carried a fourfold risk of progression compared with CN (HR = 4.1, p <0.0001).
conclusionThese results identify affective and memory-semantic factors as significant predictors of more rapid progression from normal to early stages of cognitive decline and highlight the subgroup of cognitively normal elderly with SCC as those with elevated risk of progression to MCI.
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