Evidence map›Paper›PMID 24698039›Full record

ReviewClinics in sports medicine2014

Emerging genetic basis of osteochondritis dissecans.

J Tyler Bates, John C Jacobs, Kevin G Shea, Julia Thom Oxford

Abstract readReview
In one paragraph

Review in Clinics in sports medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Proteome Alterations in Equine Osteochondrotic Chondrocytes.International journal of molecular sciences · 2019
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

J Tyler BatesDepartment of Biological Sciences, Biomolecular Research Center, Musculoskeletal Research Institute, Boise State University, 1910 University Drive, Boise, ID 83725, USA.
John C JacobsUniversity of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA.
Kevin G SheaSt. Luke's Sports Medicine, St. Luke's Health System, St. Luke's Children's Hospital, 600 North Robbins Road, Suite 400, Boise, ID 83702, USA; Department of Orthopedics, University of Utah, 590 Wakara Way, Salt Lake City, UT 84108, USA.
Julia Thom OxfordDepartment of Biological Sciences, Biomolecular Research Center, Musculoskeletal Research Institute, Boise State University, 1910 University Drive, Boise, ID 83725, USA. Electronic address: joxford@boisestate.edu.
Boise State University · USUniversity of Utah · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Scott A Minnich · 2012 to 2026
$59.8M
UNDERGRADUATE COLLEGE OUTREACH PROGRAMP20RR016454 · NCRR · UNIVERSITY OF IDAHO · PI CHASE, JENNIFER R · 2001 to 2011
$35.3M
VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI OXFORD, JULIA THOM · 2014 to 2023
$22.7M
NCRR NIH HHS P20 RR016454NIGMS NIH HHS P20 GM103408NIGMS NIH HHS P20 GM109095
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) provide an unbiased approach in the identification of genes that increase the risk for osteochondritis dissecans (OCD). Recent GWAS in humans, horses, and pigs are reviewed and genes identified. The identified genes tended to cluster with respect to function and biologic processes. GWAS in humans are a critical next step in the effort to provide a better understanding of the causes of OCD, which will, in turn, allow preventive strategies for treatment of adolescents and young adults who are at risk for the development of degenerative joint disease due to the effects of OCD.

Indexed as

Genetic Predisposition to DiseaseAnimalsExtracellular MatrixGenotypeHorse DiseasesHorsesHumansOsteochondritis DissecansSwineSwine DiseasesEquineGenome-wide association studyHumanOsteoarthritisOsteochondritis dissecansOsteochondrosisSingle nucleotide polymorphismSwine

Identifiers

PMID24698039
PMCPMC3976886
OpenAlexW1968172247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.