ArticleBrain pathology (Zurich, Switzerland)2014
Hippocampal sclerosis in feline epilepsy.
Article in Brain pathology (Zurich, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Interictal Single-Voxel Proton Magnetic Resonance Spectroscopy of the Temporal Lobe in Cats with Idiopathic Epilepsy: A Prospective Case-Control Study.Veterinary sciences · 2026Article
- Pinniped electroencephalography: Methodology and findings in California sea lions (Frontiers in veterinary science · 2023Article
- Parallel roles of neuroinflammation in feline and human epilepsies.Veterinary journal (London, England : 1997) · 2022Review
- Feline temporal lobe epilepsy: seven cases of hippocampal and piriform lobe necrosis in England and literature review.Journal of feline medicine and surgery · 2022Review
- A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation.The Journal of veterinary medical science · 2022Article
- Age-related brain atrophy in cats without apparent neurological and behavioral signs using voxel-based morphometry.Frontiers in veterinary science · 2022Article
- Article
- Partial cortico-hippocampectomy in cats, as therapy for refractory temporal epilepsy: A descriptive cadaveric study.PloS one · 2021Article
- Focal Cortical Resection and Hippocampectomy in a Cat With Drug-Resistant Structural Epilepsy.Frontiers in veterinary science · 2021Article
- Companion animal models of neurological disease.Journal of neuroscience methods · 2020Review
- Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis.Journal of veterinary internal medicine · 2019Article
- Delineation of the Feline Hippocampal Formation: A Comparison of Magnetic Resonance Images With Anatomic Slices.Frontiers in veterinary science · 2019Article
- Recurrent seizures in cats: Diagnostic approach - when is it idiopathic epilepsy?Journal of feline medicine and surgery · 2018Article
- Statistical Structural Analysis of Familial Spontaneous Epileptic Cats Using Voxel-Based Morphometry.Frontiers in veterinary science · 2018Article
- Magnetic resonance features of the feline hippocampus in epileptic and non-epileptic cats: a blinded, retrospective, multi-observer study.BMC veterinary research · 2016Article
- International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats.BMC veterinary research · 2015Article
- International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol.BMC veterinary research · 2015Article
- Porencephaly in dogs and cats: relationships between magnetic resonance imaging (MRI) features and hippocampal atrophy.The Journal of veterinary medical science · 2015Article
- LGI Proteins and Epilepsy in Human and Animals.Journal of veterinary internal medicineReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hippocampal sclerosis (HS) refers to loss of hippocampal neurons and astrogliosis. In temporal lobe epilepsy (TLE), HS is a key factor for pharmacoresistance, even though the mechanisms are not quite understood. While experimental TLE models are available, there is lack of models reflecting the natural HS development. Among domestic animals, cats may present with TLE-like seizures in natural and experimental settings. With this study on the prevalence, segmental pattern and clinicopathological correlates of feline HS, we evaluated the translational value for human research. Evaluation schemes for human brains were applied to epileptic cats. The loss of neurons was morphometrically assessed and the degree of gliosis was recorded. Hippocampal changes resembling human HS were seen in about one third of epileptic cats. Most of these were associated with infiltrative diseases such as limbic encephalitis. Irrespective of the etiology and semiology of seizures, total hippocampal sclerosis was the most prevalent form seen in epileptic animals. Other HS types also occur at varying frequencies. Segmental differences to human HS can be explained by species-specific synaptic connectivities and a different spectrum of etiologies. All these variables require consideration when translating results from feline studies regarding seizure-associated changes of the temporal lobe and especially HS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.