Evidence map›Paper›PMID 24697895›Full record

ArticleDevelopmental cell2014

Caspase-3, shears for synapse pruning.

Chengyong Shen, Wen C Xiong, Lin Mei

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Chengyong ShenDepartment of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, 1120 15(th) Street, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA.
Wen C XiongDepartment of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, 1120 15(th) Street, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA.
Lin MeiDepartment of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, 1120 15(th) Street, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA. Electronic address: lmei@gru.edu.

Funding

Mechanisms of neuromuscular junction formationR01NS082007 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2013 to 2022
$5.2M
NRG1-ErbB4 regulation of synaptic plasticity and behaviorR01MH083317 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI MEI, LIN · 2008 to 2018
$4.3M
SIGNALING MECHANISMS REGULATING ACHR SYNTHESIS AT NMJR01NS040480 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MEI, LIN · 2000 to 2013
$3.6M
NIMH NIH HHS R01 MH083317NINDS NIH HHS R01 NS040480NINDS NIH HHS R01 NS082007
6 · The paper itself

Abstract

Motor neurons regulate neuromuscular junction formation by using agrin to stimulate acetylcholine receptor clustering and using acetylcholine to disperse unnecessary receptor clusters on muscle fibers. Wang et al. (2014) now report in this issue of Developmental Cell a critical role for caspase-3 in intracellular mechanisms of acetylcholine-induced dispersal.

Indexed as

Synaptic TransmissionAdaptor Proteins, Signal TransducingAnimalsCaspase 3Dishevelled ProteinsMuscle, SkeletalNeuromuscular JunctionPhosphoproteinsSynaptic PotentialsAdaptor Proteins, Signal TransducingCaspase 3Dishevelled ProteinsPhosphoproteins

Identifiers

PMID24697895
PMCPMC4176701

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.