ArticleBritish journal of clinical pharmacology2014
Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach.
Article in British journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Monocytes as an Early Predictor for Patients with Acute Paraquat Poisoning: A Retrospective Analysis.BioMed research international · 2019Trial
- The toxicokinetics of acute paraquat poisoning in specific patients: a case series.The Journal of international medical research · 2022Article
- The efficacy of hemodialysis on paraquat poisoning mortality: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Review
- Development and validation of a sensitive and high throughput UPLC-MS/MS method for determination of paraquat and diquat in human plasma and urine: application to poisoning cases at emergency departments of hospitals.Forensic toxicology · 2022Article
- Comparison of Biochemical Parameters between Mouse Model and Human after Paraquat Poisoning.BioMed research international · 2022Article
- Paraquat lung - a rare cause of diffuse parenchymal lung disease.Acta bio-medica : Atenei Parmensis · 2021Article
- Behavioral Tests in Neurotoxin-Induced Animal Models of Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2020Review
- Identify the Early Predictor of Mortality in Patients with Acute Paraquat Poisoning.BioMed research international · 2020Article
- Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress.Toxicology research · 2019Article
- A Synthetic Receptor as a Specific Antidote for Paraquat Poisoning.Theranostics · 2019Article
- Article
- Paraquat induced acute kidney injury and lung fibrosis: a case report from Bangladesh.BMC research notes · 2018Article
- The Plasma Concentration of MUC5B Is Associated with Clinical Outcomes in Paraquat-poisoned Patients.American journal of respiratory and critical care medicine · 2018Article
- Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning.Experimental and therapeutic medicine · 2017Article
- Editor's Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinson's Disease Risk.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Pharmacometrics: so much mathematics and why planes achieve their destinations with almost perfect results ….British journal of clinical pharmacology · 2015Article
- Caenorhabditis elegans as an alternative in vivo model to determine oral uptake, nanotoxicity, and efficacy of melatonin-loaded lipid-core nanocapsules on paraquat damage.International journal of nanomedicine · 2015Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsParaquat poisoning is a medical problem in many parts of Asia and the Pacific. The mortality rate is extremely high as there is no effective treatment. We analyzed data collected during an ongoing cohort study on self-poisoning and from a randomized controlled trial assessing the efficacy of immunosuppressive therapy in hospitalized paraquat-intoxicated patients. The aim of this analysis was to characterize the toxicokinetics and toxicodynamics of paraquat in this population.
methodsA non-linear mixed effects approach was used to perform a toxicokinetic/toxicodynamic population analysis in a cohort of 78 patients.
resultsThe paraquat plasma concentrations were best fitted by a two compartment toxicokinetic structural model with first order absorption and first order elimination. Changes in renal function were used for the assessment of paraquat toxicodynamics. The estimates of toxicokinetic parameters for the apparent clearance, the apparent volume of distribution and elimination half-life were 1.17 l h(-1) , 2.4 l kg(-1) and 87 h, respectively. Renal function, namely creatinine clearance, was the most significant covariate to explain between patient variability in paraquat clearance.This model suggested that a reduction in paraquat clearance occurred within 24 to 48 h after poison ingestion, and afterwards the clearance was constant over time. The model estimated that a paraquat concentration of 429 μg l(-1) caused 50% of maximum renal toxicity. The immunosuppressive therapy tested during this study was associated with only 8% improvement of renal function.
conclusionThe developed models may be useful as prognostic tools to predict patient outcome based on patient characteristics on admission and to assess drug effectiveness during antidote drug development.
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