ArticleJournal of anatomy2014
Identification of G protein-coupled estrogen receptor in human and pig spermatozoa.
Article in Journal of anatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- New Insights from Toxinology in Mammalian Reproduction: A Systematic Review.Mini reviews in medicinal chemistry · 2025Pooled it
- Endocrine Examples of Phase Separation in Biology.Endocrinology · 2025Review
- Article
- Article
- Reduced Vitellogenesis and Female Fertility in Gper Knockout Zebrafish.Frontiers in endocrinology · 2021Article
- FSH-R Human Early Male Genital Tract, Testicular Tumors and Sperm: Its Involvement in Testicular Disorders.Life (Basel, Switzerland) · 2020Article
- Review
- The COVID-19 Pandemic: Is It A Wolf Consuming Fertility?International journal of fertility & sterility · 2020Article
- GPER and Testicular Germ Cell Cancer.Frontiers in endocrinology · 2020Review
- In vitro effect of nerve growth factor on the main traits of rabbit sperm.Reproductive biology and endocrinology : RB&E · 2019Article
- Diverse Synaptic Distributions of G Protein-coupled Estrogen Receptor 1 in Monkey Prefrontal Cortex with Aging and Menopause.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Interactions between oestrogen and 1α,25(OH)Basic and clinical andrology · 2017Article
- 17β-estradiol modifies human spermatozoa mitochondrial function in vitro.Reproductive biology and endocrinology : RB&E · 2016Article
- A novel approach to assessing bisphenol-A hazards using an in vitro model system.BMC genomics · 2016Article
- Increased expression of PELP1 in human sperm is correlated with decreased semen quality.Asian journal of andrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estrogens are known to influence functional properties of mammalian spermatozoa inducing rapid responses through the classical estrogen receptors (ERα and ERβ). Recently, the G protein-coupled estrogen receptor (GPER) has been identified as mediator of fast non-genomic estrogen effects in different cells. This work investigated the expression of GPER in human and pig spermatozoa using immunofluorescence, Western blot analysis and RT-PCR. GPER was found to be confined to the mid-piece of human sperm cells, whereas it was detected in the acrosomal region, the equatorial segment and the mid-piece of pig spermatozoa. Furthermore, in the male gametes of both species, the immunoblots of sperm extracts revealed a band at ~42 kDa, consistent with the GPER molecular weight, and RT-PCR detected the GPER transcripts. This is the first report demonstrating the expression of GPER in human and pig mature sperm cells and evidencing its species-specific cellular localization.
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Registered trials
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