Evidence map›Paper›PMID 24697276›Full record

ArticleVox sanguinis2014

Occult hepatitis B virus infection among blood donors from the Brazilian Amazon: implications for transfusion policy.

M N dos S Moresco, H de A Virgolino, M P E de Morais, I da Motta-Passos, M S Gomes-Gouvêa, L M S de Assis, K R de L Aguiar, S C F Lombardi, A Malheiro, N de P Cavalheiro and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vox sanguinis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Screening and diagnosis of HBV in low-income and middle-income countries.Nature reviews. Gastroenterology & hepatology · 2016
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

M N dos S MorescoPrograma de Pós-Graduação em Imunologia Básica e Aplicada da, Universidade Federal do Amazonas, Manaus, Amazonas, Brazil.
H de A Virgolino
M P E de Morais
I da Motta-Passos
M S Gomes-Gouvêa
L M S de Assis
K R de L Aguiar
S C F Lombardi
A Malheiro
N de P Cavalheiro
J E Levi
K L Torres
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade Federal do Amazonas · BRUniversidade Federal de São Paulo · BR

Funding

Health Outcomes in Blood Donors and RecipientsK24HL075036 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MURPHY, EDWARD L · 2004 to 2013
$1.6M
NHLBI NIH HHS K24 HL075036
6 · The paper itself

Abstract

backgroundBrazil requires the performance of both a test for hepatitis B surface antigen (HBsAg) and a test for antibodies to the core of hepatitis B for blood donor screening. Blood centres in regions of high HBV endemicity struggle to maintain adequate stocks in face of the high discard rates due to anti-HBc reactivity. We evaluated the potential infectivity of donations positive for anti-HBc in search of a rational approach for the handling of these collections. STUDY DESIGN AND

methodsWe tested anti-HBc reactive blood donations from the state of Amazonas for the presence of HBV DNA and for titres of anti-HBs. The study population consists of village-based donors from the interior of Amazonas state.

resultsAmong 3600 donations, 799 were anti-HBc reactive (22·2%). We were able to perform real-time PCR for the HBV S gene on specimens from 291 of these donors. Eight of these samples were negative for HBsAg and positive for HBV DNA and were defined as occult B virus infections (2·7%). Six of those eight specimens had anti-HBs titres above 100 mIU/ml, indicating the concomitant presence of the virus with high antibody titres.

conclusionA small proportion of anti-HBc reactive donors carry HBV DNA and anti-HBs testing is not useful for predicting viremia on them. This finding indicates the possibility of HBV transmission from asymptomatic donors, especially in areas of high HBV prevalence. Sensitive HBV DNA nucleic acid testing may provide another level of safety, allowing eventual use of anti-HBc reactive units in critical situations.

Indexed as

Blood DonorsAdultBlood TransfusionBrazilCommunicable Disease ControlDNA, ViralHepatitis BHepatitis B AntibodiesHepatitis B Core AntigensHepatitis B Surface AntigensHepatitis B virusHumansMaleMiddle AgedPrevalenceReal-Time Polymerase Chain ReactionDNA, ViralHepatitis B AntibodiesHepatitis B Core AntigensHepatitis B Surface Antigensblood donorsBrazilian AmazonHBV DNAoccult hepatitis B

Identifiers

PMID24697276
PMCPMC5047514
OpenAlexW2151380884

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.