ReviewHeadache2014
Ion channels and migraine.
Review in Headache, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Esculetin attenuates migraine-like pain via CGRP suppression and meningeal mast cell modulation in rat models.Journal of Zhejiang University. Science. B · 2026Article
- Transformer-based deep learning enhances discovery in migraine GWAS.Nature communications · 2025Article
- Evaluating the Role of Coenzyme Q10 in Migraine Therapy-A Narrative Review.Antioxidants (Basel, Switzerland) · 2025Review
- Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs.Scientific reports · 2025Article
- Migraine is a dysfunction of neuronal potassium ion channels.Frontiers in neurology · 2025Review
- Article
- Ion Channel Disturbances in Migraine Headache: Exploring the Potential Role of the Kynurenine System in the Context of the Trigeminovascular System.International journal of molecular sciences · 2023Review
- Non-coding variants in VAMP2 and SNAP25 affect gene expression: potential implications in migraine susceptibility.The journal of headache and pain · 2023Article
- Future targets for migraine treatment beyond CGRP.The journal of headache and pain · 2023Review
- Involvement of Potassium Channel Signalling in Migraine Pathophysiology.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Targeting Peripheral N-Methyl-D-Aspartate Receptor (NMDAR): A Novel Strategy for the Treatment of Migraine.Journal of clinical medicine · 2023Review
- Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools.Brain : a journal of neurology · 2022Article
- Article
- Changes in the gene expression profile during spontaneous migraine attacks.Scientific reports · 2021Article
- Overexpressed NaFrontiers in cellular neuroscience · 2021Article
- Transcriptomic sex differences in sensory neuronal populations of mice.Scientific reports · 2020Article
- From Mechanism to Cure: Renewing the Goal to Eliminate the Disease of Pain.Pain medicine (Malden, Mass.) · 2018Review
- Verapamil Inhibits TRESK (KInternational journal of molecular sciences · 2018Article
- Genetic and biochemical changes of the serotonergic system in migraine pathobiology.The journal of headache and pain · 2017Review
- Neurovascular contributions to migraine: Moving beyond vasodilation.Neuroscience · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Migraine is one of the most common neurological disorders. Despite its prevalence, the basic physiology of the molecules and mechanisms that contribute to migraine headache is still poorly understood, making the discovery of more effective treatments extremely difficult. The consistent presence of head-specific pain during migraine suggests an important role for activation of the peripheral nociceptors localized to the head. Accordingly, this review will cover the current understanding of the biological mechanisms leading to episodic activation and sensitization of the trigeminovascular pain pathway, focusing on recent advances regarding activation and modulation of ion channels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.