ReviewJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2014
Post-transcriptional regulation of cytokine signaling by AU-rich and GU-rich elements.
Review in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Human colon stem cells are the predominant epithelial responders to bacterial antigens.Frontiers in immunology · 2025Article
- The 3' Untranslated Regions of Ebola Virus mRNAs Contain AU-Rich Elements Involved in Posttranscriptional Stabilization and Decay.The Journal of infectious diseases · 2023Article
- Post-transcriptional control of T-cell cytokine production: Implications for cancer therapy.Immunology · 2021Review
- Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration.Nature communications · 2021Article
- Review
- TARBP2 promotes tumor angiogenesis and metastasis by destabilizing antiangiogenic factor mRNAs.Cancer science · 2021Article
- Human T cells employ conserved AU-rich elements to fine-tune IFN-γ production.European journal of immunology · 2020Article
- miR-424 Promotes Bovine Adipogenesis Through an Unconventional Post-Transcriptional Regulation ofFrontiers in genetics · 2020Article
- HuR controls apoptosis and activation response without effects on cytokine 3' UTRs.RNA biology · 2019Article
- miR-1306 Mediates the Feedback Regulation of the TGF-β/SMAD Signaling Pathway in Granulosa Cells.Cells · 2019Article
- Bi-phased regulation of the post-transcriptional inflammatory response by Tristetraprolin levels.RNA biology · 2019Article
- Post-Transcriptional Inflammatory Response to Intracellular Bacterial c-di-AMP.Frontiers in immunology · 2019Article
- Immune Reconstitution Disorders: Spotlight on Interferons.International journal of biomedical investigation · 2019Article
- Negative Regulation of BOK Expression by Recruitment of TRIM28 to Regulatory Elements in Its 3' Untranslated Region.iScience · 2018Article
- Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism.Neural regeneration research · 2018Review
- Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells.Nature immunology · 2018Article
- FcαRI co-stimulation converts human intestinal CD103Nature communications · 2018Article
- Post-transcriptional regulation of cytokine expression and signaling.Current trends in immunology · 2018Article
- Post-transcriptional regulation of cytokine and growth factor signaling in cancer.Cytokine & growth factor reviews · 2017Review
- Hallmarks of cancer and AU-rich elements.Wiley interdisciplinary reviews. RNA · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cytokines are necessary for cell communication to enable responses to external stimuli that are imperative for the survival and maintenance of homeostasis. Dysfunction of the cytokine network has detrimental effects on intra- and extracellular environments. Thus, it is critical that the expression of cytokines and the signals transmitted by cytokines to target cells are tightly regulated at numerous levels, including transcriptional and post-transcriptional levels. Here, we briefly summarize the role of AU-rich elements (AREs) in the regulation of cytokine gene expression at the post-transcriptional level and describe a role for GU-rich elements (GREs) in coordinating the regulation of cytokine signaling. GREs function as post-transcriptional regulators of proteins that control cellular activation, growth, and apoptosis. GREs and AREs work in concert to coordinate cytokine signal transduction pathways. The precise regulation of cytokine signaling is particularly important, because its dysregulation can lead to human diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.