Evidence map›Paper›PMID 24697191›Full record

ArticleInternational journal of cosmetic science2014

Transcriptional changes in organoculture of full-thickness human skin following topical application of all-trans retinoic acid.

J M Gillbro, T Al-Bader, M Westman, M J Olsson, A Mavon

Abstract read
In one paragraph

Article in International journal of cosmetic science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

J M GillbroOriflame Skin Research Institute, Mäster Samuelsgatan 56, Stockholm, 11121, Sweden.
T Al-Bader
M Westman
M J Olsson
A Mavon

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we developed an organoculture of human skin to investigate the effect of topical applied all-trans retinoic acid using a gene array approach. We could by using this approach confirm previous studies on genes activated by RA in keratinocyte monocultures and also provide new insights on genes that are relevant to RA-activation in human skin. The results in the present study show this model represent a valuable pre-clinical model for studying the effects of retinoids in skin.

Indexed as

AdultFemaleGene Expression ProfilingGene Expression RegulationHumansIn Vitro TechniquesMiddle AgedOligonucleotide Array Sequence AnalysisReal-Time Polymerase Chain ReactionRNASkinSkin Physiological PhenomenaTranscription, GeneticTretinoinYoung AdultRNATretinoinacnecell culturedandruffelisagenomicsproteomicsrosaceaskin culturestriae skin physiologystructure

Identifiers

PMID24697191
PMCPMC4265278

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.