ArticleBioMed research international2014
GCK gene-body hypomethylation is associated with the risk of coronary heart disease.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Epigenetic Changes Related to Hypertension in Asian Adults: A Systematic Review.Chronic diseases and translational medicine · 2025Review
- A novel Bayesian hierarchical model for detecting differential circadian pattern in transcriptomic applications.Briefings in bioinformatics · 2025Article
- G-quadruplex forming regions in GCK and TM6SF2 are targets for differential DNA methylation in metabolic disease and hepatocellular carcinoma patients.Scientific reports · 2024Article
- Review
- Efficient detection of differentially methylated regions in the genome of patients with thoracic aortic dissection and association with MMP2 hypermethylation.Experimental and therapeutic medicine · 2020Article
- Association of GCK gene DNA methylation with the risk of clopidogrel resistance in acute coronary syndrome patients.Journal of clinical laboratory analysis · 2020Article
- DNA Methylation Analysis Identifies Differentially Methylated Sites Associated with Early-Onset Intracranial Atherosclerotic Stenosis.Journal of atherosclerosis and thrombosis · 2020Article
- Article
- Differentially methylated regions in patients with rheumatic heart disease and secondary pulmonary arterial hypertension.Experimental and therapeutic medicine · 2017Article
- Hypermethylation of brain natriuretic peptide gene is associated with the risk of rheumatic heart disease.Bioscience reports · 2017Article
- An integrated approach to coronary heart disease diagnosis and clinical management.American journal of translational research · 2017Review
- Article
- SSTR2 promoter hypermethylation is associated with the risk and progression of laryngeal squamous cell carcinoma in males.Diagnostic pathology · 2016Article
- Article
- Elevation of peripheral BDNF promoter methylation links to the risk of Alzheimer's disease.PloS one · 2014Article
- Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men.Clinical epigenetics · 2014Article
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesGlucokinase encoded by GCK is a key enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Variants of GCK gene were shown to be associated with type 2 diabetes (T2D) and coronary heart disease (CHD). The goal of this study was to investigate the contribution of GCK gene-body methylation to the risk of CHD. DESIGN AND
methods36 patients (18 males and 18 females) and 36 age- and sex-matched controls were collected for the current methylation research. DNA methylation level of the CpG island (CGI) region on the GCK gene-body was measured through the sodium bisulfite DNA conversion and pyrosequencing technology.
resultsOur results indicated that CHD cases have a much lower methylation level (49.77 ± 6.43%) compared with controls (54.47 ± 7.65%, P = 0.018). In addition, GCK gene-body methylation was found to be positively associated with aging in controls (r = 0.443, P = 0.010).
conclusionsOur study indicated that the hypomethylation of GCK gene-body was significantly associated with the risk of CHD. Aging correlates with an elevation of GCK methylation in healthy controls.
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