ArticleJournal of advanced pharmaceutical technology & research2014
Synthesis and antinociceptive activity of novel mannich base derivatives of some new fused 3,5-pyrazolidinedione.
Article in Journal of advanced pharmaceutical technology & research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 14 citations in OpenAlex.
- Antinociceptive activities of Artocarpus lacucha Buch-ham (Moraceae) and its isolated phenolic compound, catechin, in mice.BMC complementary and alternative medicine · 2019Article
- Polymethoxyflavones fromFrontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, a novel series of mannich bases 1-((1-substituted ethyl-1H-benzo[d] imidazol-2-yl) methyl)-2-substituted phenylpyrazolidine-3,5-dione 3(a-l) were synthesized and evaluated as antinociceptive agents in mice by Eddy's hot plate and acetic acid-induced writhing models. The structures attributed to compounds 3a-3l were elucidated by using IR, 1H-NMR, and Mass spectroscopic techniques. Some compounds showed promising analgesic activity when compared with the standard drug Diclofenac sodium. Results of analgesic activity via hot plate model showed that compounds 3d and 3f were found to be more active than standard drug. Results of analgesic activity via acetic acid-induced writhing model showed that compounds 3a, 3c, 3k, and 3l showed activity which is comparable with the standard drug.
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Registered trials
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