ReviewJournal of reproduction & infertility2014
Human sperm DNA fragmentation and its correlation with conventional semen parameters.
Review in Journal of reproduction & infertility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- Sperm DNA fragmentation and its impact on pregnancy outcomes: a narrative review focusing on threshold definition and clinical strategies.Translational andrology and urology · 2026Review
- Single-Molecule approach to quantify sperm single-stranded DNA damage using the novel sperm repair-assisted damage detection (SRADD) assay.Journal of assisted reproduction and genetics · 2026Article
- Flow Cytometric Assessment of Sperm DNA Fragmentation by TUNEL and Acridine Orange: Methodological and Clinical Insights.Journal of clinical medicine · 2026Article
- Molecular Characterization ofInfectious disease reports · 2025Article
- Article
- High sperm DNA stainability might not be an accurate predictive indicator of male fertility and assisted reproductive technology outcomes.Frontiers in endocrinology · 2025Article
- Anacyclus pyrethrum enhances fertility in cadmium-intoxicated male rats by improving sperm functions.BMC complementary medicine and therapies · 2024Article
- External quality assessment scheme for sperm DNA fragmentation: a pilot study in China.Basic and clinical andrology · 2023Article
- Zinc-nanoparticles alleviate the ovarian damage induced by bacterial lipopolysaccharide (LPS) in pregnant rats and their fetuses.Histochemistry and cell biology · 2023Article
- Electroacupuncture Effectiveness for Treating Idiopathic Male Infertility.Medical acupuncture · 2022Article
- Review
- Variability in Sperm DNA Fragmentation in Men with Mild/Unexplained Subfertility in a Prospective Longitudinal Intrauterine Insemination Trial.Life (Basel, Switzerland) · 2022Article
- Evolution of the World Health Organization semen analysis manual: where are we?Nature reviews. Urology · 2022Review
- Male factor testing in recurrent pregnancy loss cases: A narrative review.International journal of reproductive biomedicine · 2022Review
- Article
- The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress.International journal of environmental research and public health · 2022Article
- Studying the mechanism of sperm DNA damage caused by folate deficiency.Journal of cellular and molecular medicine · 2022Article
- Adverse effects of oxytetracycline and enrofloxacin on the fertility of Saanen bucks.Tropical animal health and production · 2021Article
- Label-Free Evaluation of Chromatin Condensation in Human Normal Morphology Sperm Using Raman Spectroscopy.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Chronic Prostatitis/Chronic Pelvic Pain Syndrome Leads to Impaired Semen Parameters, Increased Sperm DNA Fragmentation and Unfavorable Changes of Sperm Protamine mRNA Ratio.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe initial step in the diagnostic investigation of male infertility has been traditionally based on the conventional seminal profile. However, there are significant limitations regarding its ability to determine the underlying mechanisms that cause the disorder. Sperm DNA fragmentation has emerged as a potential causative factor of reproductive failure and its assessment has been suggested as a useful adjunct to the laboratory methodology of male infertility evaluation, especially before the application of assisted reproduction technology (ART).
methodsA review of recent bibliography was carried out in PubMed by the use of relevant keywords, in order to evaluate the possible correlation between the conventional seminal parameters and sperm DNA fragmentation assessment as diagnostic tools in male infertility evaluation.
resultsA comprehensive diagnostic approach of male infertility should be based on a combination of diagnostic attributes, derived from the conventional semen analysis, as well as the investigation of genomic integrity testing.
conclusionDue to its strong correlation with several aspects of ART procedures and further consequences for the offspring, sperm DNA fragmentation is a parameter worth integrating in routine clinical practice. However, additional large scale studies focusing on specific subgroups of infertile men who may benefit from an efficient therapeutic management based on the optimization of sperm DNA integrity are needed.
Indexed as
Identifiers
24696791PMC3955419What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.