ReviewInternational journal of fertility & sterility2014
Premature ovarian failure: a critical condition in the reproductive potential with various genetic causes.
Review in International journal of fertility & sterility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The impact of FMR1 gene mutations on human reproduction and development: a systematic review.Journal of assisted reproduction and genetics · 2016Pooled it
- Mesenchymal stem cells and platelet rich plasma in the treatment of premature ovarian insufficiency: a scoping review.Contraception and reproductive medicine · 2025Review
- Icariin inhibits cisplatin-induced ovarian toxicity via modulating NF-κB and PTEN/AKT/mTOR/AMPK axis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- An overview of different methods to establish a murine premature ovarian failure model.Animal models and experimental medicine · 2024Review
- Effect and mechanism of pearl on ovarian function of rats with premature ovarian failure induced by tripterygium glycosides.Journal of traditional and complementary medicine · 2023Article
- CXCL10-based gene cluster model serves as a potential diagnostic biomarker for premature ovarian failure.PeerJ · 2023Article
- Chromosomal abnormalities detected by karyotyping among patients with secondary amenorrhea: a retrospective study.Sao Paulo medical journal = Revista paulista de medicina · 2023Article
- Primary ovarian insufficiency quality of life scale (POIQOLS): development and psychometric properties.BMC women's health · 2022Review
- Rapid ovarian transcript changes during the onset of premature ovarian insufficiency.Reproduction & fertility · 2022Article
- CPEB3 deficiency in mice affect ovarian follicle development and causes premature ovarian insufficiency.Cell death & disease · 2021Article
- Incidence and prevalence of primary ovarian insufficiency in South Korea: a population-based study.Archives of gynecology and obstetrics · 2021Article
- Transplantation of human umbilical cord mesenchymal stem cells to treat premature ovarian failure.Stem cell research & therapy · 2021Review
- A 15q25.2 microdeletion phenotype for premature ovarian failure in a Chinese girl: a case report and review of literature.BMC medical genomics · 2020Review
- Characterization of the Metabolic, Clinical and Neuropsychological Phenotype of Female Carriers of the Premutation in the X-LinkedFrontiers in molecular biosciences · 2020Article
- TMCO1 is essential for ovarian follicle development by regulating ER CaCell death and differentiation · 2018Article
- Review
- A Novel Missense Mutation in the CLPP Gene Causing Perrault Syndrome Type 3 in a Turkish Family.Journal of clinical research in pediatric endocrinology · 2016Article
- Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases.Human reproduction (Oxford, England) · 2016Article
- Early menopause: A hazard to a woman's health.The Indian journal of medical research · 2016Review
- Single nucleotide polymorphisms in premature ovarian failure-associated genes in a Chinese Hui population.Molecular medicine reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Premature ovarian failure (POF) is identified as a heterogeneous disorder leading to amenorrhea and ovarian failure before the age of 40 years. The first known symptom of the disease is having irregular menstrual periods. The phenotype appearance of POF depends significantly on the variations in hormones. Low levels of gonadal hormones (estrogens and inhibins) and increased level of gonadotropins [luteinizing hormone (LH) and Follicle stimulating hormone (FSH)] (hypergonadotropic amenorrhea) are well documented as causes of POF. There is an association between the failure of germ cell development and complete ovarian failure, and consistently decreased number of germ cells is more likely associated with partial ovarian failure resulting in secondary amenorrhea. A literature review on recent findings about POF and its association with genomic alterations in terms of genes and chromosomes. POF is a complex heterogeneous disorder. Some of POF cases are carriers of a single gene mutation inherited in an autosomal or X-linked manner while a number of patients suffer from a chromosome abnormality like Turner syndrome in mosaic form and manifest secondary amenorrhea associated with ovarian dysgenesis. Among many of the known involved genes in POF development, several are prove to be positively associated to the disease development in different populations. While there is a promising association between X chromosome anomalies and specific gene mutations with POF, genome-wide analysis could prove a powerful tool for identifying the most important candidate genes that influence POF manifestation.
Indexed as
Identifiers
24696764PMC3973172W2132662501What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.